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Literature summary for 2.3.2.2 extracted from

  • Sachdev, G.P.; Leahy, D.S.; Chace, K.V.
    Phenobarbital and related compounds as novel inhibitors of gamma-glutamyltranspeptidase (1983), Biochim. Biophys. Acta, 749, 125-129.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
hexobarbital
-
Rattus norvegicus
Phenobarbital active site-directed, irreversible inactivation, optimal at pH 9.0, serine/borate or GSH protects, maleate protects slightly, kinetics Rattus norvegicus
Thiobarbituric acid active site-directed, irreversible inactivation, optimal at pH 9.5, serine/borate or GSH protects, maleate protects slightly, kinetics Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male, Sprague-Dawley
-

Reaction

Reaction Comment Organism Reaction ID
a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid active site on small subunit Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5-L-glutamyl)-peptide + acceptor + H+
-
Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
?
5-L-glutamyl-4-nitroanilide + glycylglycine
-
Rattus norvegicus 4-nitroaniline + 5-L-glutamylglycylglycine
-
?

Subunits

Subunits Comment Organism
More small subunit MW: 20000 Rattus norvegicus
More the active site resides on the small subunit Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
20
-
Thiobarbituric acid
-
Rattus norvegicus
30
-
hexobarbital
-
Rattus norvegicus
43
-
Phenobarbital
-
Rattus norvegicus