Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.2.13 extracted from

  • Ponnusamy, M.; Pang, M.; Annamaraju, P.K.; Zhang, Z.; Gong, R.; Chin, Y.E.; Zhuang, S.
    Transglutaminase-1 protects renal epithelial cells from hydrogen peroxide-induced apoptosis through activation of STAT3 and AKT signaling pathways (2009), Am. J. Physiol. Renal Physiol., 297, F1361-F1370.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.2.13

Inhibitors

Inhibitors Comment Organism Structure
Monodansylcadaverine
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
renal proximal tubule
-
 Mus musculus
-

Expression

Organism Comment Expression
Mus musculus eposure of renal proximal tubule cells to hydrogen peroxide resultsin apoptosis and an increase in TGase activity up

General Information

General Information Comment Organism
physiological function inhibition of TGase activity with monodansylcadervine, or knockdown of TGase-1 with small interference RNA enhances apoptosis and decreased cell survival in hydrogen peroxide-treated renal proximal tubule cells. Overexpression of TGase-1 renders renal proximal tubule cells more resistant to hydrogen peroxide toxicity and monodansylcadaverine treatment blocks this response. Concurrent with renal proximal tubule cells apoptosis, phosphorylation of AKT, signal transducer and activator of transcription-3, and glucogen synthase kinase-3 are observed. Pretreatment of cells with monodansylcadervine or TGase-1 siRNA inhibits phosphorylation of all these molecules Mus musculus