Literature summary for 2.3.2.13 extracted from

Maiuri, L.; Luciani, A.; Giardino, I.; Raia, V.; Villella, V.R.; DApolito, M.; Pettoello-Mantovani, M.; Guido, S.; Ciacci, C.; Cimmino, M.; Cexus, O.N.; Londei, M.; Quaratino, S.
Tissue transglutaminase activation modulates inflammation in cystic fibrosis via PPARgamma down-regulation (2008), J. Immunol., 180, 7697-7705.

Search for more literature for 2.3.2.13

Application

Application	Comment	Organism
medicine	central role of TG2 in the mechanistic pathway of CF inflammation, opening a possible new wave of therapies for sufferers of chronic inflammatory diseases	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
bronchial epithelial cell	ex vivo cultures of nasal polyp mucosal explants of Cystic fibrosis patients and controls, cystic fibrosis transmembrane conductance regulator-defective IB3-1 bronchial epithelial cells, C38 isogenic CFTR corrected, and 16HBE normal bronchial epithelial cell lines. A defective cystic fibrosis transmembrane conductance regulator induces a remarkable up-regulation of tissue transglutaminase in both tissues and cell lines. The increased TG2 activity leads to functional sequestration of the anti-inflammatory peroxisome proliferator-activated receptor gamma and increase of the classic parameters of inflammation	Homo sapiens	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)