Application | Comment | Organism |
---|---|---|
medicine | enzyme activity is implicated in the pathogenesis of diseases related to wound healing and neovascularization. Enzyme deficient cells display normal attachment but delayed spreading on extracellular matrix substrates and defects in motility unrelated to crosslinking. Enzyme deficient fibroblasts have defects in focal adhesion turnover and stress fibre formation, show changes in focal adhesion kinase phosphorylation and fail to activate protein kinase C alpha | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | enzyme is involved in the control of dynamic adhesion formation in cell spreading and migration via regulation of phospholipase C activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
patients with deficiencies in enzyme activity | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | primary foreskin fibroblast | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme is involved in the control of dynamic adhesion formation in cell spreading and migration via regulation of phospholipase C activity | Homo sapiens | ? | - |
? |