Activating Compound | Comment | Organism | Structure |
---|---|---|---|
thrombin | - |
Cavia porcellus | |
thrombin | - |
Homo sapiens | |
thrombin | guinea pig epidermal enzyme | Rattus norvegicus | |
thrombin | particulate enzyme | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
iodoacetamide | - |
Cavia porcellus | |
iodoacetamide | - |
Homo sapiens | |
iodoacetamide | 86% and 91% inhibition of chondrosarcoma transglutaminase B and C respectively | Rattus norvegicus | |
additional information | - |
Cavia porcellus | |
additional information | - |
Homo sapiens | |
additional information | not inhibited by diisopropylfluorophosphate; not inhibited by PMSF; not inhibited by sulfhydryl-reagents in the absence of Ca2+ | Rattus norvegicus | |
N-iodoacetyl-N'-(5-sulfo-1-naphthyl)ethylenediamine | 0.01 mM, 91% and 92% inhibition of chondrosarcoma transglutaminases B and C respectively | Rattus norvegicus | |
p-chloromercuribenzoate | - |
Cavia porcellus | |
p-chloromercuribenzoate | 21% inhibition of chondrosarcoma transglutaminase B | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Cavia porcellus | |
additional information | - |
additional information | - |
Homo sapiens | |
additional information | - |
additional information | kinetic study with various transglutaminases: human factor XIIIa, guinea pig liver TGC, rat chondrosarcoma TGB | Rattus norvegicus | |
0.024 | - |
methylamine | transglutaminase C | Cavia porcellus | |
0.051 | - |
methylamine | chondrosarcoma transglutaminase B | Rattus norvegicus | |
0.061 | - |
methylamine | factor XIIIa | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
particle-bound | - |
Cavia porcellus | - |
- |
particle-bound | - |
Homo sapiens | - |
- |
particle-bound | - |
Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | requirement | Cavia porcellus | |
Ca2+ | requirement | Homo sapiens | |
Ca2+ | requirement | Rattus norvegicus | |
Mn2+ | - |
Cavia porcellus | |
Mn2+ | - |
Homo sapiens | |
Mn2+ | slight activation | Rattus norvegicus | |
additional information | - |
Homo sapiens | |
additional information | not activated by Cu2+ | Rattus norvegicus | |
Sr2+ | - |
Cavia porcellus | |
Sr2+ | slight activation | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
80000 | - |
- |
Homo sapiens |
80000 | - |
liver and chondrosarcoma transglutaminase C, gel filtration | Rattus norvegicus |
100000 | - |
liver and chondrosarcoma transglutaminase B | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
- |
- |
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | chondrosarcoma transglutaminase | Rattus norvegicus |
Purification (Comment) | Organism |
---|---|
partial | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
chondrocyte | malignant, swarm chondrosarcoma | Rattus norvegicus | - |
liver | - |
Cavia porcellus | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
methylamine + succinyl-beta-casein | transglutaminase B | Rattus norvegicus | ? | - |
? | |
methylamine + succinylated alpha-casein | - |
Cavia porcellus | ? | - |
? | |
protein-bound gamma-glutamine + alkylamine | - |
Cavia porcellus | protein N5-alkylglutamine + NH3 | - |
? | |
protein-bound gamma-glutamine + alkylamine | - |
Homo sapiens | protein N5-alkylglutamine + NH3 | - |
? | |
protein-bound gamma-glutamine + alkylamine | chondrosarcoma transglutaminase B, no activity with type I collagen and fibronectin | Rattus norvegicus | protein N5-alkylglutamine + NH3 | - |
? | |
protein-bound gamma-glutamine + alkylamine | transglutaminase B: simultaneously gamma-polymer and alpha-polymer formation | Rattus norvegicus | protein N5-alkylglutamine + NH3 | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.32 | - |
methylamine | chondrosarcoma transglutaminase B | Rattus norvegicus | |
0.467 | - |
methylamine | transglutaminase C | Cavia porcellus | |
1.86 | - |
methylamine | factor XIIIa | Homo sapiens |