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Literature summary for 2.3.2.12 extracted from
- Catalytic mechanism of L,D-transpeptidase 2 from Mycobacterium tuberculosis described by a computational approach: insights for the design of new antibiotics drugs (2014), J. Chem. Inf. Model., 54, 2402-2410.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| peptidyl-tRNA1 + aminoacyl-tRNA2 | Mycobacterium tuberculosis | - |
tRNA1 + peptidyl(aminoacyl-tRNA2) | - |
? |  |
| peptidyl-tRNA1 + aminoacyl-tRNA2 | Mycobacterium tuberculosis CDC 1551 | - |
tRNA1 + peptidyl(aminoacyl-tRNA2) | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | O53223 | - |
- |
| Mycobacterium tuberculosis CDC 1551 | O53223 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| peptidyl-tRNA1 + aminoacyl-tRNA2 | - |
Mycobacterium tuberculosis | tRNA1 + peptidyl(aminoacyl-tRNA2) | - |
? | |
| peptidyl-tRNA1 + aminoacyl-tRNA2 | - |
Mycobacterium tuberculosis CDC 1551 | tRNA1 + peptidyl(aminoacyl-tRNA2) | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| L,D-transpeptidase 2 | - |
Mycobacterium tuberculosis |
| LdtMt2 | - |
Mycobacterium tuberculosis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme catalyzes the formation of 3 -> 3 peptidoglycan cross-links of the cell wall and facilitates resistance against classical beta-lactams | Mycobacterium tuberculosis |
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Release 2023.1 (January 2023)
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