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Literature summary for 2.3.2.12 extracted from

  • Kalpaxis, D.L.; Drainas D.
    Inhibitory effect of spermine on ribosomal peptidyltransferase (1993), Arch. Biochem. Biophys., 300, 629-634.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
spermine competitive inhibitor of peptide bond formation at the kinetic phase of the puromycin reaction Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
ribosome additionally factors washable from ribosomes Escherichia coli 5840
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peptidyl-tRNA1 + alpha-aminoacyl-tRNA2 Escherichia coli
-
tRNA1 + peptidyl-amino-tRNA2
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
B cells
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
AcPhe-tRNA + puromycin
-
Escherichia coli tRNA + AcPhe-puromycin
-
?
peptidyl-tRNA1 + alpha-aminoacyl-tRNA2
-
Escherichia coli tRNA1 + peptidyl-amino-tRNA2
-
?