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Literature summary for 2.3.2.11 extracted from
- Alanyl-phosphatidylglycerol and lysyl-phosphatidylglycerol are translocated by the same MprF flippases and have similar capacities to protect against the antibiotic daptomycin in Staphylococcus aureus (2012), Antimicrob. Agents Chemother., 56, 3492-3497.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in a mprF deletion mutant of Staphylococcus aureus | Clostridium perfringens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Clostridium perfringens | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Ala-PG synthase | - |
Clostridium perfringens |
| MprF1 | - |
Clostridium perfringens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | MprF1-mediated alanyl-phosphatidylglycerol production in Staphylococcus aureus does not affect susceptibility to gallidermin and nisin and leads to only a minor decrease in daptomycin susceptibility. Coexpression of the enzyme with flippase domains of lysyl-phosphatidylglycerol synthesizing MprF proteins leads to a wild type level of daptomycin susceptibility | Clostridium perfringens |
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Release 2023.1 (January 2023)
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