Application | Comment | Organism |
---|---|---|
medicine | Fem transferases are considered as attractive targets for the development of novel antibiotics active against multi-resistant bacteria | Weissella viridescens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
oxa-helixAla | - |
Weissella viridescens | |
oxa-helixGly | - |
Weissella viridescens | |
oxa-helixSer | - |
Weissella viridescens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Weissella viridescens | FemXWv transferase adds the first residue of the L-Ala-L-Ser-L-Ala side chain onto the nucleotide precursor UDP-MurNAc-pentadepsipeptide | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Weissella viridescens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Weissella viridescens |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
relative activity of FemXWv for the transfer of L-Ala from helixAla to UDP-MurNAc-pentapeptide 100% | Weissella viridescens |
additional information | - |
relative activity of FemXWv for the transfer of L-Ala from helixGly to UDP-MurNAc-pentapeptide 2.9% | Weissella viridescens |
additional information | - |
relative activity of FemXWv for the transfer of L-Ala from helixSer to UDP-MurNAc-pentapeptide 31% | Weissella viridescens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | FemXWv transferase adds the first residue of the L-Ala-L-Ser-L-Ala side chain onto the nucleotide precursor UDP-MurNAc-pentadepsipeptide | Weissella viridescens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FemXWv transferase | - |
Weissella viridescens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
inhibition assay | Weissella viridescens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
inhibition assay | Weissella viridescens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0014 | - |
- |
Weissella viridescens | oxa-helixAla | |
0.015 | - |
- |
Weissella viridescens | oxa-helixSer | |
0.067 | - |
- |
Weissella viridescens | oxa-helixGly |