Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli as a C-terminally hexahistidine-tagged protein | Saccharolobus solfataricus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + [DNA-binding protein Alba1]-L-lysine16 | Saccharolobus solfataricus | the DNA binding affinity of the chromatin protein Alba is regulated by acetylation of lysine16. Acetylation lowers the affinity of Alba for DNA. The acetyltransferase is conserved also in bacteria where it appears to play a role in metabolic regulation. The data suggest that Sulfolobus solfataricus has coopted this bacterial regulatory system to generate a rudimentary form of chromatin regulation | CoA + [DNA-binding protein Alba1]-N6-acetyl-L-lysine16 | - |
? | |
acetyl-CoA + [DNA-binding protein Alba1]-L-lysine16 | Saccharolobus solfataricus P2 | the DNA binding affinity of the chromatin protein Alba is regulated by acetylation of lysine16. Acetylation lowers the affinity of Alba for DNA. The acetyltransferase is conserved also in bacteria where it appears to play a role in metabolic regulation. The data suggest that Sulfolobus solfataricus has coopted this bacterial regulatory system to generate a rudimentary form of chromatin regulation | CoA + [DNA-binding protein Alba1]-N6-acetyl-L-lysine16 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharolobus solfataricus | Q97V23 | - |
- |
Saccharolobus solfataricus P2 | Q97V23 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Saccharolobus solfataricus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + [DNA-binding protein Alba1]-L-lysine16 | the DNA binding affinity of the chromatin protein Alba is regulated by acetylation of lysine16. Acetylation lowers the affinity of Alba for DNA. The acetyltransferase is conserved also in bacteria where it appears to play a role in metabolic regulation. The data suggest that Sulfolobus solfataricus has coopted this bacterial regulatory system to generate a rudimentary form of chromatin regulation | Saccharolobus solfataricus | CoA + [DNA-binding protein Alba1]-N6-acetyl-L-lysine16 | - |
? | |
acetyl-CoA + [DNA-binding protein Alba1]-L-lysine16 | the enzyme specifically acetylates protein Alba1 (SSO0962) on L-lysine 16 | Saccharolobus solfataricus | CoA + [DNA-binding protein Alba1]-N6-acetyl-L-lysine16 | - |
? | |
acetyl-CoA + [DNA-binding protein Alba1]-L-lysine16 | the DNA binding affinity of the chromatin protein Alba is regulated by acetylation of lysine16. Acetylation lowers the affinity of Alba for DNA. The acetyltransferase is conserved also in bacteria where it appears to play a role in metabolic regulation. The data suggest that Sulfolobus solfataricus has coopted this bacterial regulatory system to generate a rudimentary form of chromatin regulation | Saccharolobus solfataricus P2 | CoA + [DNA-binding protein Alba1]-N6-acetyl-L-lysine16 | - |
? | |
acetyl-CoA + [DNA-binding protein Alba1]-L-lysine16 | the enzyme specifically acetylates protein Alba1 (SSO0962) on L-lysine 16 | Saccharolobus solfataricus P2 | CoA + [DNA-binding protein Alba1]-N6-acetyl-L-lysine16 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SSO2813 | locus name | Saccharolobus solfataricus |
ssPat | - |
Saccharolobus solfataricus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
65 | - |
assay at | Saccharolobus solfataricus |
70 | 90 | - |
Saccharolobus solfataricus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Saccharolobus solfataricus |
General Information | Comment | Organism |
---|---|---|
physiological function | the DNA binding affinity of the chromatin protein Alba1 is regulated by acetylation of lysine16. Acetylation lowers the affinity of Alba for DNA | Saccharolobus solfataricus |