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Literature summary for 2.3.1.97 extracted from

  • Ohta, H.; Takamune, N.; Kishimoto, N.; Shoji, S.; Misumi, S.
    N-Myristoyltransferase 1 enhances human immunodeficiency virus replication through regulation of viral RNA expression level (2015), Biochem. Biophys. Res. Commun., 463, 988-993.
    View publication on PubMed

Application

Application Comment Organism
medicine both NMT1 and hnRNP A2/B1 may take part in the regulation of HIV-1 RNA expression through their mutual opposite effects on the viral RNA expression in HIV-1-producing cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
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Homo sapiens
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TZM-bl cell
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Homo sapiens
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General Information

General Information Comment Organism
physiological function several RNA-binding proteins including ribosomal proteins, NMT isozymes, and hnRNP A2/B1 bind to NMT1, as mediated mainly by RNA. Only hRNP A2/B1 associates with NMT1 without mediation by RNA. Knockdown of hnRNP A2/B1 results in the enhancement of viral replication with an increase in the expression level of viral RNA in HIV-1-producing cells. Knockdown of NMT1 results in the attenuation of viral replication with the decrease in the expression level of viral RNA in HIV-1-producing cells. Overexpression of NMT1 induces the enhancement of viral replication with the increase in the expression level of the viral RNA Homo sapiens