Application | Comment | Organism |
---|---|---|
medicine | both NMT1 and hnRNP A2/B1 may take part in the regulation of HIV-1 RNA expression through their mutual opposite effects on the viral RNA expression in HIV-1-producing cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
TZM-bl cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | several RNA-binding proteins including ribosomal proteins, NMT isozymes, and hnRNP A2/B1 bind to NMT1, as mediated mainly by RNA. Only hRNP A2/B1 associates with NMT1 without mediation by RNA. Knockdown of hnRNP A2/B1 results in the enhancement of viral replication with an increase in the expression level of viral RNA in HIV-1-producing cells. Knockdown of NMT1 results in the attenuation of viral replication with the decrease in the expression level of viral RNA in HIV-1-producing cells. Overexpression of NMT1 induces the enhancement of viral replication with the increase in the expression level of the viral RNA | Homo sapiens |