Protein Variants | Comment | Organism |
---|---|---|
additional information | NMT1 knockdown increases apoptosis in activated neutrophils | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | NMT1 in endothelium | Bos taurus | 5737 | - |
nucleus | NMT1 in endothelium | Bos taurus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
tetradecanoyl-CoA + glycylpeptide | Bos taurus | i.e. myristoyl-CoA, the enzyme attaches the fatty acid to a glycine at the N-terminus of proteins | CoA + N-tetradecanoyl-glycylpeptide | - |
? |
Organic Solvent | Comment | Organism |
---|---|---|
a | - |
Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
two isozymes NMT1 and NMT2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colorectal carcinoma cell | elevated NMT1 expression | Bos taurus | - |
endothelium | lung, NMT1 | Bos taurus | - |
epithelium | airway, NMT1 | Bos taurus | - |
lung | - |
Bos taurus | - |
macrophage | intravascular, high NMT1 expression | Bos taurus | - |
neutrophil | high NMT1 expression in neutrophils from the necrotic areas in inflamed lungs | Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
tetradecanoyl-CoA + glycylpeptide | i.e. myristoyl-CoA, the enzyme attaches the fatty acid to a glycine at the N-terminus of proteins | Bos taurus | CoA + N-tetradecanoyl-glycylpeptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
N-myristoyltransferase | - |
Bos taurus |
NMT | - |
Bos taurus |
Organism | Comment | Expression |
---|---|---|
Bos taurus | NMT1 expression in increased in macrophages and neutrophils after Escherichia coli lipopolysacchride application | up |
General Information | Comment | Organism |
---|---|---|
malfunction | expression of isozyme NMT1 is reduced in lung inflammation and induced by Mannheimer hemolytica, probably due to increased enolase expression | Bos taurus |
physiological function | NMT plays a role in the regulation of neutrophil lifespan, overview. Myristoylated proteins play critical roles in protein-protein interactions, cell signaling and oncogenesis | Bos taurus |