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Literature summary for 2.3.1.97 extracted from

  • Shrivastav, A.; Suri, S.; Mohr, R.; Janardhan, K.; Sharma, R.; Singh, B.
    Expression and activity of N-myristoyltransferase in lung inflammation of cattle and its role in neutrophil apoptosis (2010), Vet. Res., 41, 9.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information NMT1 knockdown increases apoptosis in activated neutrophils Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm NMT1 in endothelium Bos taurus 5737
-
nucleus NMT1 in endothelium Bos taurus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
tetradecanoyl-CoA + glycylpeptide Bos taurus i.e. myristoyl-CoA, the enzyme attaches the fatty acid to a glycine at the N-terminus of proteins CoA + N-tetradecanoyl-glycylpeptide
-
?

Organic Solvent Stability

Organic Solvent Comment Organism
a
-
Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
two isozymes NMT1 and NMT2
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal carcinoma cell elevated NMT1 expression Bos taurus
-
endothelium lung, NMT1 Bos taurus
-
epithelium airway, NMT1 Bos taurus
-
lung
-
Bos taurus
-
macrophage intravascular, high NMT1 expression Bos taurus
-
neutrophil high NMT1 expression in neutrophils from the necrotic areas in inflamed lungs Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tetradecanoyl-CoA + glycylpeptide i.e. myristoyl-CoA, the enzyme attaches the fatty acid to a glycine at the N-terminus of proteins Bos taurus CoA + N-tetradecanoyl-glycylpeptide
-
?

Synonyms

Synonyms Comment Organism
N-myristoyltransferase
-
Bos taurus
NMT
-
Bos taurus

Expression

Organism Comment Expression
Bos taurus NMT1 expression in increased in macrophages and neutrophils after Escherichia coli lipopolysacchride application up

General Information

General Information Comment Organism
malfunction expression of isozyme NMT1 is reduced in lung inflammation and induced by Mannheimer hemolytica, probably due to increased enolase expression Bos taurus
physiological function NMT plays a role in the regulation of neutrophil lifespan, overview. Myristoylated proteins play critical roles in protein-protein interactions, cell signaling and oncogenesis Bos taurus