Literature summary for 2.3.1.97 extracted from

Sheng, C.; Ji, H.; Miao, Z.; Che, X.; Yao, J.; Wang, W.; Dong, G.; Guo, W.; Lue, J.; Zhang, W.
Homology modeling and molecular dynamics simulation of N-myristoyltransferase from protozoan parasites: active site characterization and insights into rational inhibitor design (2009), J. Comput. Aided Mol. Des., 23, 375-389.

Inhibitors

Inhibitors	Comment	Organism
2-([[(1R,3S)-3-[[(5-chloro-7-methylnaphthalen-2-yl)methyl]amino]cyclohexyl]acetyl]amino)-N,N-dimethyl-1,3-benzothiazole-6-carboxamide	-	Leishmania major
2-([[(1R,3S)-3-[[(5-chloro-7-methylnaphthalen-2-yl)methyl]amino]cyclohexyl]acetyl]amino)-N,N-dimethyl-1,3-benzothiazole-6-carboxamide	-	Plasmodium falciparum
2-([[(1R,3S)-3-[[(5-chloro-7-methylnaphthalen-2-yl)methyl]amino]cyclohexyl]acetyl]amino)-N,N-dimethyl-1,3-benzothiazole-6-carboxamide	-	Trypanosoma brucei
2-([[4-(aminomethyl)cyclohexyl]carbonyl]amino)-N,N-dimethyl-1,3-benzothiazole-6-carboxamide	-	Leishmania major
2-([[4-(aminomethyl)cyclohexyl]carbonyl]amino)-N,N-dimethyl-1,3-benzothiazole-6-carboxamide	-	Plasmodium falciparum
2-([[4-(aminomethyl)cyclohexyl]carbonyl]amino)-N,N-dimethyl-1,3-benzothiazole-6-carboxamide	-	Trypanosoma brucei
2-[([(1R,3S)-3-[(1-benzofuran-5-ylmethyl)amino]cyclohexyl]acetyl)amino]-N,N-dimethyl-1,3-benzothiazole-6-carboxamide	-	Leishmania major
2-[([(1R,3S)-3-[(1-benzofuran-5-ylmethyl)amino]cyclohexyl]acetyl)amino]-N,N-dimethyl-1,3-benzothiazole-6-carboxamide	-	Plasmodium falciparum
2-[([(1R,3S)-3-[(1-benzofuran-5-ylmethyl)amino]cyclohexyl]acetyl)amino]-N,N-dimethyl-1,3-benzothiazole-6-carboxamide	-	Trypanosoma brucei
2-[([(1R,3S)-3-[(1-benzofuran-6-ylmethyl)amino]cyclohexyl]acetyl)amino]-N,N-dimethyl-1,3-benzothiazole-6-carboxamide	-	Leishmania major
2-[([(1R,3S)-3-[(1-benzofuran-6-ylmethyl)amino]cyclohexyl]acetyl)amino]-N,N-dimethyl-1,3-benzothiazole-6-carboxamide	-	Plasmodium falciparum
2-[([(1R,3S)-3-[(1-benzofuran-6-ylmethyl)amino]cyclohexyl]acetyl)amino]-N,N-dimethyl-1,3-benzothiazole-6-carboxamide	-	Trypanosoma brucei
2-[([(1R,3S)-3-[(1H-indol-5-ylmethyl)amino]cyclohexyl]acetyl)amino]-N,N-dimethyl-1,3-benzothiazole-6-carboxamide	-	Leishmania major
2-[([(1R,3S)-3-[(1H-indol-5-ylmethyl)amino]cyclohexyl]acetyl)amino]-N,N-dimethyl-1,3-benzothiazole-6-carboxamide	-	Plasmodium falciparum
2-[([(1R,3S)-3-[(1H-indol-5-ylmethyl)amino]cyclohexyl]acetyl)amino]-N,N-dimethyl-1,3-benzothiazole-6-carboxamide	-	Trypanosoma brucei
3,3'-[(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methanediyl]bis(6-hydroxybenzoic acid)	-	Leishmania major
3,3'-[(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methanediyl]bis(6-hydroxybenzoic acid)	-	Plasmodium falciparum
3,3'-[(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methanediyl]bis(6-hydroxybenzoic acid)	-	Trypanosoma brucei
4-(4,5-dihydroxy-9-methyl-3-oxo-1,3,3a,4,9,9a-hexahydronaphtho[2,3-c]furan-1-yl)-2,5-dihydroxybenzamide	-	Leishmania major
4-(4,5-dihydroxy-9-methyl-3-oxo-1,3,3a,4,9,9a-hexahydronaphtho[2,3-c]furan-1-yl)-2,5-dihydroxybenzamide	-	Plasmodium falciparum
4-(4,5-dihydroxy-9-methyl-3-oxo-1,3,3a,4,9,9a-hexahydronaphtho[2,3-c]furan-1-yl)-2,5-dihydroxybenzamide	-	Trypanosoma brucei
cis-4-[(naphthalen-2-ylmethyl)amino]-N-(6-pyridin-2-yl-1,3-benzothiazol-2-yl)cyclohexanecarboxamide	-	Leishmania major
cis-4-[(naphthalen-2-ylmethyl)amino]-N-(6-pyridin-2-yl-1,3-benzothiazol-2-yl)cyclohexanecarboxamide	-	Plasmodium falciparum
cis-4-[(naphthalen-2-ylmethyl)amino]-N-(6-pyridin-2-yl-1,3-benzothiazol-2-yl)cyclohexanecarboxamide	-	Trypanosoma brucei
cis-N-(6-fluoro-1,3-benzothiazol-2-yl)-4-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide	-	Leishmania major
cis-N-(6-fluoro-1,3-benzothiazol-2-yl)-4-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide	-	Plasmodium falciparum
cis-N-(6-fluoro-1,3-benzothiazol-2-yl)-4-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide	-	Trypanosoma brucei
cis-N-1,3-benzothiazol-2-yl-4-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide	-	Leishmania major
cis-N-1,3-benzothiazol-2-yl-4-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide	-	Plasmodium falciparum
cis-N-1,3-benzothiazol-2-yl-4-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide	-	Trypanosoma brucei
additional information	binding mode, structure-activity relationship and selectivity of inhibitors, overview. The enzyme is a target for rational inhibitor design, modelling of inhibitor docking, overview	Leishmania major
additional information	binding mode, structure-activity relationship and selectivity of inhibitors, overview. The enzyme is a target for rational inhibitor design, modelling of inhibitor docking, overview	Plasmodium falciparum
additional information	binding mode, structure-activity relationship and selectivity of inhibitors, overview. The enzyme is a target for rational inhibitor design, modelling of inhibitor docking, overview	Trypanosoma brucei

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Trypanosoma brucei	5829	-
cytosol	-	Leishmania major	5829	-
cytosol	-	Plasmodium falciparum	5829	-

Organism

Organism	UniProt	Comment	Textmining
Leishmania major	Q9GPZ4	-	-
Plasmodium falciparum	Q9U419	-	-
Trypanosoma brucei	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
additional information	active site structure, overview	Trypanosoma brucei	?	-	?
additional information	active site structure, overview	Leishmania major	?	-	?
additional information	active site structure, overview	Plasmodium falciparum	?	-	?
tetradecanoyl-CoA + glycylpeptide	i.e. myristoyl-CoA, the enzyme attaches the fatty acid to a glycine at the N-terminus of a number of eukaryotic cellular and viral proteins	Trypanosoma brucei	CoA + N-tetradecanoyl-glycylpeptide	-	?
tetradecanoyl-CoA + glycylpeptide	i.e. myristoyl-CoA, the enzyme attaches the fatty acid to a glycine at the N-terminus of a number of eukaryotic cellular and viral proteins	Leishmania major	CoA + N-tetradecanoyl-glycylpeptide	-	?
tetradecanoyl-CoA + glycylpeptide	i.e. myristoyl-CoA, the enzyme attaches the fatty acid to a glycine at the N-terminus of a number of eukaryotic cellular and viral proteins	Plasmodium falciparum	CoA + N-tetradecanoyl-glycylpeptide	-	?

Subunits

Subunits	Comment	Organism
More	three-dimensional model formation using the cyrstal structure and homology modeling method, and energy minimization and molecular dynamics simulations	Trypanosoma brucei
More	three-dimensional model formation using the cyrstal structure and homology modeling method, and energy minimization and molecular dynamics simulations	Leishmania major
More	three-dimensional model formation using the cyrstal structure and homology modeling method, and energy minimization and molecular dynamics simulations	Plasmodium falciparum

Synonyms

Synonyms	Comment	Organism
myristoyl-CoA:protein N-myristoyltransferase	-	Trypanosoma brucei
myristoyl-CoA:protein N-myristoyltransferase	-	Leishmania major
myristoyl-CoA:protein N-myristoyltransferase	-	Plasmodium falciparum
N-myristoyltransferase	-	Trypanosoma brucei
N-myristoyltransferase	-	Leishmania major
N-myristoyltransferase	-	Plasmodium falciparum
NMT	-	Trypanosoma brucei
NMT	-	Leishmania major
NMT	-	Plasmodium falciparum