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Literature summary for 2.3.1.97 extracted from

  • Raju, R.V.S.; Kakkar, R.; Datla, R.S.S.; Radhi, J.; Sharma, R.K.
    Myristoyl-CoA:protein N-myristoyltransferase from bovine cardiac muscle: molecular cloning, kinetic analysis, and in vitro proteolytic cleavage by m-calpain (1998), Exp. Cell Res., 241, 23-35.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
cloning of cardiac muscle enzyme, expression in Escherichia coli, DNA and amino acid sequence determination Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
m-calpain enzyme is inactivated by cleavage, protease is specific for PEST regions, i.e. regions rich in proline, glutamic acid, serine and threonine, calpain-inhibitor calpastatin protects Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0058
-
myristoyl-CoA recombinant enzyme Bos taurus
0.016
-
p60src-derived peptide recombinant enzyme Bos taurus
0.05
-
M2 gene segment of reovirus type 3-derived peptide recombinant enzyme Bos taurus
0.1
-
cAMP-dependent protein kinase-derived peptide recombinant enzyme Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol major part Bos taurus 5829
-
mitochondrion occasionally Bos taurus 5739
-
myofibril occasionally Bos taurus 30016
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
amino acid sequence, alignment Bos taurus
50000
-
1 * 50000, recombinant enzyme Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
myristoyl-CoA + glycylpeptide Bos taurus enzyme is possibly regulated by calpains in vivo N-myristoylglycylpeptide + CoA
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
cardiac muscle enzyme, recombinant from Escherichia coli Bos taurus

Reaction

Reaction Comment Organism Reaction ID
tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal-N-tetradecanoylglycyl-[protein] PEST regions for recognition by clapains, putative regulatory enzymes Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
cardiac muscle cardiac, low activity Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
myristoyl-CoA + cAMP-dependent protein kinase-derived peptide
-
Bos taurus N-myristoylated cAMP-dependent protein kinase-derived peptide + CoA
-
?
myristoyl-CoA + Gly-Ser-Ser-Lys-Ser-Lys-Pro-Lys-Arg pp60src-derived peptide Bos taurus N-myristoyl-Gly-Ser-Ser-Lys-Ser-Lys-Pro-Lys-Arg + CoA
-
?
myristoyl-CoA + glycylpeptide substrate specificity Bos taurus N-myristoylglycylpeptide + CoA
-
?
myristoyl-CoA + glycylpeptide enzyme is possibly regulated by calpains in vivo Bos taurus N-myristoylglycylpeptide + CoA
-
?
myristoyl-CoA + M2 gene segment of reovirus type 3-derived peptide
-
Bos taurus N-myristoylated M2 gene segment of reovirus type 3-derived peptide + CoA
-
?
palmitoyl-CoA + glycylpeptide poor substrate Bos taurus N-palmitoylglycylpeptide + CoA
-
?

Subunits

Subunits Comment Organism
monomer 1 * 50000, recombinant enzyme Bos taurus

Synonyms

Synonyms Comment Organism
NMT
-
Bos taurus