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Literature summary for 2.3.1.94 extracted from

  • Pfeifer, B.A.; Admiraal, S.J.; Gramajo, H.; Cane, D.E.; Khosla, C.
    Biosynthesis of complex polyketides in a metabolically engieered strain of Escherichia coli (2001), Science, 291, 1790-1792.
    View publication on PubMed

Application

Application Comment Organism
biotechnology a derivative of Escherichia coli is genetically engineered to produce 6-deoxyerythronolide B, the macrocyclic core of the antibiotic erythromycin Saccharopolyspora erythraea

Cloned(Commentary)

Cloned (Comment) Organism
a variant of DEBS1 is cloned into the vector pET21c Saccharopolyspora erythraea
into the vector pET21c Saccharopolyspora erythraea

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
332000
-
-
Saccharopolyspora erythraea
370000
-
-
Saccharopolyspora erythraea
380000
-
-
Saccharopolyspora erythraea

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+ Saccharopolyspora erythraea
-
6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
-
?

Organism

Organism UniProt Comment Textmining
Saccharopolyspora erythraea Q03131
-
-
Saccharopolyspora erythraea Q03132
-
-
Saccharopolyspora erythraea Q03133
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+
-
Saccharopolyspora erythraea 6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
-
?

Synonyms

Synonyms Comment Organism
DEBS1
-
Saccharopolyspora erythraea
DEBS2
-
Saccharopolyspora erythraea
DEBS3
-
Saccharopolyspora erythraea
deoxyerythronolide B synthase 1
-
Saccharopolyspora erythraea
deoxyerythronolide B synthase 2
-
Saccharopolyspora erythraea
deoxyerythronolide B synthase 3
-
Saccharopolyspora erythraea
PKS
-
Saccharopolyspora erythraea
polyketide synthase
-
Saccharopolyspora erythraea