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Literature summary for 2.3.1.94 extracted from

  • Wong, F.T.; Chen, A.Y.; Cane, D.E.; Khosla, C.
    Protein-protein recognition between acyltransferases and acyl carrier proteins in multimodular polyketide synthases (2010), Biochemistry, 49, 95-102.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
the acyltransferase domains, AT1, AT2, AT4, AT5 and AT6, from DEBS are expressed as stand-alone proteins with their ketosynthase-to-acyltransferase and post-acyltransferase linkers, ketosynthase3-acyltransferase3 and ketosynthase6-acyltransferase6 didomains and discrete acyl carrier protein domain expression vectors are constructed, the vector pET28a is used for expression in Escherichia coli BL21DE3 cells Saccharopolyspora erythraea

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Saccharopolyspora erythraea

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+ Saccharopolyspora erythraea
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6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
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?

Organism

Organism UniProt Comment Textmining
Saccharopolyspora erythraea Q03131
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-

Purification (Commentary)

Purification (Comment) Organism
-
Saccharopolyspora erythraea

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+
-
Saccharopolyspora erythraea 6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
-
?

Subunits

Subunits Comment Organism
More DEBS is organized into modules comprising of multiple catalytic domains, to assemble short acyl-CoA precursors into complex polyketide products, each module contains minimally three functional domains, a beta-ketosynthase, an acyltransferase, and an acyl carrier protein Saccharopolyspora erythraea

Synonyms

Synonyms Comment Organism
6-deoxyerythronolide B synthase
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Saccharopolyspora erythraea
DEBS
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Saccharopolyspora erythraea