KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | both isoforms Aanat1a and Aanat1b display 2- to 3fold lower KM values for indolethylamines compared to phenylethylamines. KM for phenylethylamines is around two times lower for Aanat1a than for Aanat1b | Dicentrarchus labrax |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Dicentrarchus labrax | A0A0K1H4R1 | isoform Aanat2 | - |
Dicentrarchus labrax | B9TU30 | isoform Aanat1a | - |
Dicentrarchus labrax | B9TU31 | isoform Aanat1b | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
nervous system | isoforms Aanat1a and Aanat1b display a wide and distinct distribution in the nervous system and peripheral tissues | Dicentrarchus labrax | - |
pineal gland | transcripts are detected almost exclusively in the pineal gland | Dicentrarchus labrax | - |
retina | traces of transcripts are detected | Dicentrarchus labrax | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + dopamine | - |
Dicentrarchus labrax | CoA + N-acetyldopamine | - |
? | |
acetyl-CoA + phenylethylamine | - |
Dicentrarchus labrax | CoA + N-acetylphenylethylamine | - |
? | |
acetyl-CoA + serotonin | best substrate | Dicentrarchus labrax | CoA + N-acetylserotonin | - |
? | |
acetyl-CoA + tryptamine | - |
Dicentrarchus labrax | CoA + N-acetyltryptamine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
arylalkylamine N-acetyltransferase 1a | - |
Dicentrarchus labrax |
arylalkylamine N-acetyltransferase 1b | - |
Dicentrarchus labrax |
arylalkylamine N-acetyltransferase 2 | - |
Dicentrarchus labrax |
General Information | Comment | Organism |
---|---|---|
physiological function | Aanat1 isoforms have a broad range of functions including melatonin synthesis in the retina, and catabolism of serotonin and dopamine in the retina and other tissues | Dicentrarchus labrax |
physiological function | isoform Aanat2 is a pineal enzyme involved in melatonin production | Dicentrarchus labrax |