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Literature summary for 2.3.1.87 extracted from

  • Falcon, J.; Besseau, L.; Fuentes, M.; Sauzet, S.; Magnanou, E.; Boeuf, G.
    Structural and functional evolution of the pineal melatonin system in vertebrates (2009), Ann. N. Y. Acad. Sci., 1163, 101-111.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + serotonin vertebrata
-
 CoA + N-acetylserotonin
-
 ?

Organism

Organism UniProt Comment Textmining
vertebrata
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 vertebrata
-
eye
-
 vertebrata
-
pineal gland photoreceptor cells, enzyme activity is regulated by circadian system, the photoperiodic control is direct in fish and frogs and indirect in mammals. Structural and functional evolution of the melatonin-producing units in vertebrates, overview vertebrata
-
retina
-
 vertebrata
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + serotonin
-
 vertebrata CoA + N-acetylserotonin
-
 ?

Synonyms

Synonyms Comment Organism
AANAT
-
 vertebrata
More evolution of AANAT subtypes in vertebrates, overview vertebrata

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
additional information
-
 pineal AANAT responds to temperature in a species-specific manner vertebrata

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the rate-limiting step in melatonin synthesis, melatonin biosynthesis pathway overview vertebrata
physiological function the enzyme catalyzes the rate-limiting step in melatonin synthesis, melatonin is a hormone acting as a synchronizer for the circadian system, overview. Evolution of the pineal gland and the circadian system involving melatonin, overview vertebrata