Literature summary for 2.3.1.85 extracted from

Hopperton, K.E.; Duncan, R.E.; Bazinet, R.P.; Archer, M.C.
Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity (2014), Exp. Cell Res., 320, 302-310.

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Application

Application	Comment	Organism
medicine	endogenously synthesized fatty acids do not fulfill a specific function in cancer cells. Cancer cells do not produce fatty acids that are different from those derived from exogenous palmitate, these fatty acids are esterified to the same lipid and phospholipid classes in the same proportions, and their distribution within neutral lipids is not different from untransformed cells. Anoxia increases glycolysis 2-3fold, with no concomitant increase in lipogenesis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-10A cell	-	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)