Literature summary for 2.3.1.85 extracted from

Li, B.H.; Ma, X.F.; Wang, Y.; Tian, W.X.
Structure-activity relationship of polyphenols that inhibit fatty acid synthase (2005), J. Biochem., 138, 679-685.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4',6,7-trihydroxylisoflavone	IC50: 0.0295 mM	Anas platyrhynchos
apigenin	IC50: 0.0176 mM	Anas platyrhynchos
daidzein	IC50: 0.0732 mM	Anas platyrhynchos
genistein	0.0287 mM	Anas platyrhynchos
iso-liquiritigenin	IC50: 0.0088 mM	Anas platyrhynchos
additional information	a common model is proposed that is possibly shared by all FAS polyphenol inhibitors. The model includes two almost planar aromatic rings with their respective hydroxyl groups, and a proper ester linkage between the two rings that possibly causes the inhibition of FAS by irreversibly inhibiting the beta-ketoacyl reductase domain	Anas platyrhynchos
nordihydroguaiaretic acid	inhibits competitively with respect to acetyl-CoA, noncompetitively with respect to malonyl-CoA, and in a mixed manner with respect toNADPH.IC50 = 0.093 mM	Anas platyrhynchos
phloretin	0.0261 mM	Anas platyrhynchos
resveratrol	IC50: 0.0085 mM	Anas platyrhynchos

Organism

Organism	UniProt	Comment	Textmining
Anas platyrhynchos	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+	-	Anas platyrhynchos	palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0085	-	IC50: 0.0085 mM	Anas platyrhynchos	resveratrol
0.0088	-	IC50: 0.0088 mM	Anas platyrhynchos	iso-liquiritigenin
0.0176	-	IC50: 0.0176 mM	Anas platyrhynchos	apigenin
0.0295	-	IC50: 0.0295 mM	Anas platyrhynchos	4',6,7-trihydroxylisoflavone
0.0732	-	IC50: 0.0732 mM	Anas platyrhynchos	daidzein
0.093	-	inhibits competitively with respect to acetyl-CoA, noncompetitively with respect to malonyl-CoA, and in a mixed manner with respect toNADPH.IC50 = 0.093 mM	Anas platyrhynchos	nordihydroguaiaretic acid

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Release 2023.1 (January 2023)