Literature summary for 2.3.1.85 extracted from

Agostini, M.; Silva, S.D.; Zecchin, K.G.; Coletta, R.D.; Jorge, J.; Loda, M.; Graner, E.
Fatty acid synthase is required for the proliferation of human oral squamous carcinoma cells (2004), Oral Oncol., 40, 728-735.

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Application

Application	Comment	Organism
medicine	androgen-independent expression of enzyme in oral SSC cells, enzyme activity is necessary for their proliferation	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
cerulenin	significant reduction of proliferation of cell lines	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
squamous cell carcinoma cell	oral squamous carcinoma cell lines SCC-4, SCC-9, SCC-15, SCC-25, differential expression of enzyme being highest in SCC-9 followed by SCC-25	Homo sapiens	-

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Release 2023.1 (January 2023)