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Literature summary for 2.3.1.85 extracted from

  • Wang, X.; Song, K.S.; Guo, Q.X.; Tian, W.X.
    The galloyl moiety of green tea catechins is the critical structural feature to inhibit fatty-acid synthase (2003), Biochem. Pharmacol., 66, 2039-2047.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
(+)-catechin 50% inhibition of overall enzyme reaction at 1.6 mM, 50% inhibition of ketoacyl reduction reaction at 7.4 mM Gallus gallus
(-)-epicatechin 50% inhibition of overall enzyme reaction at 3.8 mM, 50% inhibition of ketoacyl reduction reaction at 9.38 mM Gallus gallus
(-)-epicatechin gallate 50% inhibition of overall enzyme reaction at 0.042 mM, 50% inhibition of ketoacyl reduction reaction at 0.068 mM, two-step inhibition mechanism with reversible initial inhibition and irreversible subsequent inactivation Gallus gallus
(-)-epigallocatechin gallate 0.5 mM, 20% residual activity, 50% inhibition of overall enzyme reaction at 0.052 mM, 50% inhibition of ketoacyl reduction reaction at 0.1 mM Gallus gallus
3,4-dihydroxybenzoic acid 50% inhibition of overall enzyme reaction at 9.0 mM, 50% inhibition of ketoacyl reduction reaction at 30 mM Gallus gallus
catechol 50% inhibition of overall enzyme reaction at 7.4 mM, 50% inhibition of ketoacyl reduction reaction at 21 mM Gallus gallus
gallic acid 50% inhibition of overall enzyme reaction at 21 mM, 50% inhibition of ketoacyl reduction reaction at 26 mM Gallus gallus
propyl gallate 50% inhibition of overall enzyme reaction at 0.5 mM, 50% inhibition of ketoacyl reduction reaction at 1.4 mM Gallus gallus
propyl p-hydroxylbenzoate 50% inhibition of overall enzyme reaction at 1.1 mM, 50% inhibition of ketoacyl reduction reaction at 2.6 mM Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Gallus gallus
-