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Literature summary for 2.3.1.82 extracted from

  • Lin, D.L.; Tran, T.; Alam, J.Y.; Herron, S.R.; Ramirez, M.S.; Tolmasky, M.E.
    Inhibition of aminoglycoside 6-N-acetyltransferase type Ib by zinc: reversal of amikacin resistance in Acinetobacter baumannii and Escherichia coli by a zinc ionophore (2014), Antimicrob. Agents Chemother., 58, 4238-4241.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Zn2+ growth of Acinetobacter baumannii or Escherichia coli harboring aac(6')-Ib in cultures containing 8 microg/ml amikacin is significantly inhibited by the addition of 2 microM Zn2+ in complex with the ionophore pyrithione Acinetobacter baumannii

Organism

Organism UniProt Comment Textmining
Acinetobacter baumannii
-
-
-
Acinetobacter baumannii 155
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + amikacin
-
Acinetobacter baumannii CoA + 6'-N-acetylamikacin
-
?
acetyl-CoA + amikacin
-
Acinetobacter baumannii 155 CoA + 6'-N-acetylamikacin
-
?

Synonyms

Synonyms Comment Organism
AAC(6')-Ib
-
Acinetobacter baumannii

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.015
-
pH not specified in the publication, temperature not specified in the publication Acinetobacter baumannii Zn2+