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Literature summary for 2.3.1.82 extracted from

  • Chowdhury, G.; Pazhani, G.P.; Nair, G.B.; Ghosh, A.; Ramamurthy, T.
    Transferable plasmid-mediated quinolone resistance in association with extended-spectrum beta-lactamases and fluoroquinolone-acetylating aminoglycoside-6-N-acetyltransferase in clinical isolates of Vibrio fluvialis (2011), Int. J. Antimicrob. Agents, 38, 169-173.
    View publication on PubMed

Application

Application Comment Organism
medicine two isolates resistant to fluoroquinolones and beta-lactam antimicrobials show mutations in the quinolone resistance-determining regions of gene GyrA and of ParC as well as carrying a 150 kb plasmid harbouring the quinolone resistance gene qnrA1, the ciprofloxacin-modifying enzyme-encoding gene aac(6')-Ib-cr and genes encoding for extended-spectrum beta-lactamases such as blaSHV and blaCTX-M-3. When this large plasmid is transferred to Escherichia coli by conjugation, the transconjugants show a 10-75fold increase in the minimum inhibitory concentrations of ciprofloxacin and norfloxacin Vibrio fluvialis

Organism

Organism UniProt Comment Textmining
Vibrio fluvialis
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