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Literature summary for 2.3.1.82 extracted from

  • Shmara, A.; Weinsetel, N.; Dery, K.J.; Chavideh, R.; Tolmasky, M.E.
    Systematic analysis of a conserved region of the aminoglycoside 6'-N-acetyltransferase type Ib (2001), Antimicrob. Agents Chemother., 45, 3287-3292.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.82

Protein Variants

Protein Variants Comment Organism
C165A mutant enzyme shows levels of resistance to both antibiotics no more than threefold lower than that for the wild type Klebsiella pneumoniae
E167A highly reduced ability to confer resistance to kanamycin and amikacin Klebsiella pneumoniae
E172A mutant enzyme shows levels of resistance to both antibiotics no more than threefold lower than that for the wild type Klebsiella pneumoniae
G170A mutant enzyme confers high-level resistance to kanamycin but loses the ability to confer resistance to amikacin Klebsiella pneumoniae
G175A mutant enzyme shows levels of resistance to both antibiotics no more than threefold lower than that for the wild type Klebsiella pneumoniae
I163A the percentage of loss of resistance to one of the two antibiotics, kanamycin and amikacin, is no more than twice the percentage of loss of resistance to the other antibiotic Klebsiella pneumoniae
K168A the percentage of loss of resistance to one of the two antibiotics, kanamycin and amikacin, is no more than twice the percentage of loss of resistance to the other antibiotic Klebsiella pneumoniae
L160A the percentage of loss of resistance to one of the two antibiotics, kanamycin and amikacin, is no more than twice the percentage of loss of resistance to the other antibiotic Klebsiella pneumoniae
N159A mutant enzyme confers high-level resistance to kanamycin but loses the ability to confer resistance to amikacin Klebsiella pneumoniae
P155A the percentage of loss of resistance to one of the two antibiotics, kanamycin and amikacin, is no more than twice the percentage of loss of resistance to the other antibiotic Klebsiella pneumoniae
P157A the percentage of loss of resistance to one of the two antibiotics, kanamycin and amikacin, is no more than twice the percentage of loss of resistance to the other antibiotic Klebsiella pneumoniae
Q174A mutant enzyme shows levels of resistance to both antibiotics no more than threefold lower than that for the wild type Klebsiella pneumoniae
R164A mutant enzyme shows levels of resistance to both antibiotics no more than threefold lower than that for the wild type Klebsiella pneumoniae
R173A mutant enzyme shows levels of resistance to both antibiotics no more than threefold lower than that for the wild type Klebsiella pneumoniae
S156A mutant enzyme shows levels of resistance to both antibiotics no more than threefold lower than that for the wild type Klebsiella pneumoniae
S158A mutant enzyme shows levels of resistance to both antibiotics no more than threefold lower than that for the wild type Klebsiella pneumoniae
S158A the MICs of amikacin and kanamycin are higher than those for the wild-type enzyme Klebsiella pneumoniae
Y166A mutant enzyme confers high-level resistance to kanamycin but loses the ability to confer resistance to amikacin Klebsiella pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Klebsiella pneumoniae involved in resistance to antibiotics ?
-
 ?

Organism

Organism UniProt Comment Textmining
Klebsiella pneumoniae Q93TA5 plasmid pJHC-MW1 mutant AAC6'-IbG175A 6'-N-acetyltransferase gene
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Klebsiella pneumoniae Q93TA6 plasmid pJHC-MW1 mutant AAC6'-IbQ174A 6'-N-acetyltransferase gene
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Klebsiella pneumoniae Q93TA7 plasmid pJHC-MW1 mutant AAC6'-IbR173A 6'-N-acetyltransferase gene
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Klebsiella pneumoniae Q93TA8 plasmid pJHC-MW1 mutant AAC6'-IbE172A 6'-N-acetyltransferase gene
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Klebsiella pneumoniae Q93TA9 plasmid pJHC-MW1 mutant AAC6'-IbF171A 6'-N-acetyltransferase gene
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Klebsiella pneumoniae Q93TB0 plasmid pJHC-MW1 mutant AAC6'-IbG170A 6'-N-acetyltransferase gene
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Klebsiella pneumoniae Q93TB1 plasmid pJHC-MW1 mutant AAC6'-IbK168A 6'-N-acetyltransferase gene
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Klebsiella pneumoniae Q93TB2 plasmid pJHC-MW1 mutant AAC6'-IbE167A 6'-N-acetyltransferase gene
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Klebsiella pneumoniae Q93TB3 plasmid pJHC-MW1 mutant AAC6'-IbY166A 6'-N-acetyltransferase gene
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Klebsiella pneumoniae Q93TB4 plasmid pJHC-MW1 mutant AAC6'-IbC165A 6'-N-acetyltransferase gene
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Klebsiella pneumoniae Q93TB5 plasmid pJHC-MW1 mutant AAC6'-IbR164A 6'-N-acetyltransferase gene
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Klebsiella pneumoniae Q93TB6 plasmid pJHC-MW1 mutant AAC6'-IbI163A 6'-N-acetyltransferase gene
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Klebsiella pneumoniae Q93TB7 plasmid pJHC-MW1 mutant AAC6'-IbR161A 6'-N-acetyltransferase gene
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Klebsiella pneumoniae Q93TB8 plasmid C-MW1 mutant AAC6'-IbL160A 6'-N-acetyltransferase gene
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Klebsiella pneumoniae Q93TB9 plasmid C-MW1 mutant AAC6'-IbN159A 6'-N-acetyltransferase gene
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Klebsiella pneumoniae Q93TC0 plasmid pJHC-MW1 mutant AAC6'-IbS158A 6'-N-acetyltransferase gene
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Klebsiella pneumoniae Q93TC1 plasmid pJHC-MW1 mutant AAC6'-IbP157A 6'-N-acetyltransferase gene
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Klebsiella pneumoniae Q93TC2 plasmid pJHC-MW1 mutant AAC6'-IbS156A 6'-N-acetyltransferase gene
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Klebsiella pneumoniae Q93TC3 plasmid pJHC-MW1 mutant AAC6'-IbP155A 6'-N-acetyltransferase gene
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information acetylation reaction occurs through a direct mechanism rather than a ping-pong mechanism that includes a transient transfer of the acetyl group to a cysteine residue Klebsiella pneumoniae ?
-
 ?
additional information involved in resistance to antibiotics Klebsiella pneumoniae ?
-
 ?