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Literature summary for 2.3.1.8 extracted from

  • Dimou, M.; Venieraki, A.; Zografou, C.; Katinakis, P.
    The cytoplasmic cyclophilin from Azotobacter vinelandii interacts with phosphate acetyltransferase isoforms enhancing their in vitro activity (2012), Mol. Biol. Rep., 39, 4135-4143.
    View publication on PubMed
Search for more literature for 2.3.1.8

Activating Compound

Activating Compound Comment Organism Structure
PPIB cytoplasmic cytophilin, interaction with phosphate acetyltransferase leads to enhanced activity and alteration in Km value. PPIase activity is not essential for these interactions, as PPIB F99A active site mutant still interacts with phosphate acetyltransferase, but PPIB activity is responsible for the observed phosphate acetyltransferase activity enhancement Azotobacter vinelandii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.041
-
 acetyl-CoA pH 7.2, 35°C, presence of 10fold molar excess of activator PPIB Azotobacter vinelandii
0.13
-
 CoA pH 7.2, 35°C, presence of 10fold molar excess of activator PPIB Azotobacter vinelandii
0.219
-
 CoA pH 7.2, 35°C, presence of 10fold molar excess of activator PPIB Azotobacter vinelandii
0.464
-
 acetyl phosphate pH 7.2, 35°C, presence of 10fold molar excess of activator PPIB Azotobacter vinelandii
0.616
-
 acetyl phosphate pH 7.2, 35°C, presence of 10fold molar excess of activator PPIB Azotobacter vinelandii
12.3
-
 phosphate pH 7.2, 35°C, presence of 10fold molar excess of activator PPIB Azotobacter vinelandii

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Azotobacter vinelandii C1DER7 isoform Pta-2
-
Azotobacter vinelandii C1DQG8 isoform Pta-1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl phosphate + CoA
-
 Azotobacter vinelandii acetyl-CoA + phosphate
-
 ?
acetyl-CoA + phosphate
-
 Azotobacter vinelandii acetyl Phosphate + CoA
-
 ?

Synonyms

Synonyms Comment Organism
Pta-1
-
 Azotobacter vinelandii
Pta-2
-
 Azotobacter vinelandii