Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Triton X-100 | 1.5 to 2.5fold stimulation at 0.25% w/v | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + heparan sulfate alpha-D-glucosaminide | Homo sapiens | - |
CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide | - |
? | |
additional information | Homo sapiens | enzyme deficiency leads to Sanfilippo syndrome type C, i.e. mucopolysaccharidosis III C | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leukocyte | deficiency on leukocytes from patients with Sanfillippo syndrome type C | Homo sapiens | - |
skin fibroblast | deficiency on fibroblasts from patients with Sanfillippo syndrome type C | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
Sanfilippo syndrome type C patients in comparison | Homo sapiens |
0.000017 | - |
leukocyte, substrate 4-methylumbelliferyl-alpha-D-glucosaminide + acetyl-CoA | Homo sapiens |
0.000022 | - |
leukocyte, substrate 4-methylumbelliferyl-beta-D-glucosaminide + acetyl-CoA | Homo sapiens |
0.000058 | - |
fibroblast, substrate 4-methylumbelliferyl-beta-D-glucosaminide + acetyl-CoA | Homo sapiens |
0.000059 | - |
fibroblast, substrate 4-methylumbelliferyl-alpha-D-glucosaminide + acetyl-CoA | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 4-methylumbelliferyl-alpha-D-glucosaminide | - |
Homo sapiens | CoA + 4-methylumbelliferyl-N-acetyl-alpha-D-glucosaminide | - |
? | |
acetyl-CoA + 4-methylumbelliferyl-beta-D-glucosaminide | - |
Homo sapiens | CoA + 4-methylumbelliferyl-N-acetyl-beta-D-glucosaminide | - |
? | |
acetyl-CoA + heparan sulfate alpha-D-glucosaminide | - |
Homo sapiens | CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide | - |
? | |
additional information | enzyme deficiency leads to Sanfilippo syndrome type C, i.e. mucopolysaccharidosis III C | Homo sapiens | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.7 | - |
- |
Homo sapiens |