Application | Comment | Organism |
---|---|---|
medicine | neutral lipid synthesis enzyme acyl-CoA:diacylglycerol acyltransferase DGAT1 functions as the major acyl-CoA:retinol acyltransferase. When dietary retinol is abundant, DGAT1 deficiency results in elevated levels of retinoic acid in skin and cyclical hair loss, both are prevented by dietary retinol deprivation. DGAT1-deficient skin exhibits enhanced sensitivity to topically administered retinol. Deletion of the enzyme specifically in the epidermis causes alopecia | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skin | neutral lipid synthesis enzyme acyl-CoA:diacylglycerol acyltransferase 1 functions as the major acyl-CoA:retinol acyltransferase | Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | neutral lipid synthesis enzyme acyl-CoA:diacylglycerol acyltransferase DGAT1 functions as the major acyl-CoA:retinol acyltransferase. When dietary retinol is abundant, DGAT1 deficiency results in elevated levels of retinoic acid in skin and cyclical hair loss, both are prevented by dietary retinol deprivation. DGAT1-deficient skin exhibits enhanced sensitivity to topically administered retinol. Deletion of the enzyme specifically in the epidermis causes alopecia | Mus musculus |