Cloned (Comment) | Organism |
---|---|
gene AWAT1, i.e. DGA2, location on the X chromosome Xq13.1, DNA and amino acid sequence determination and analysis, expression analysis, expression in Saccharomyces cerevisiae | Homo sapiens |
gene DC3, DNA and amino acid sequence determination and analysis, genetic organization and phylogenetics, expression in Saccharomyces cerevisiae | Homo sapiens |
gene DC4, DNA and amino acid sequence determination and analysis, genetic organization and phylogenetics, expression in Saccharomyces cerevisiae | Homo sapiens |
gene DC4, i.e. AWAT2, location on the X chromosome Xq13.1, DNA and amino acid sequence determination and analysis, expression analysis, expression in Saccharomyces cerevisiae | Homo sapiens |
gene DGAT2, DNA and amino acid sequence determination and analysis, genetic organization and phylogenetics, expression in Saccharomyces cerevisiae | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + long-chain diacylglycerol | Homo sapiens | - |
CoA + long-chain triacylglycerol | - |
? | |
acyl-CoA + long-chain fatty alcohol | Homo sapiens | - |
CoA + long-chain fatty ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q58HT5 | AWAT1, i.e. DGA2; X-linked gene AWAT1/DGA2 | - |
Homo sapiens | Q58HT5 | gene DGAT2L3; isozyme DGA2 or AWAT1 | - |
Homo sapiens | Q6E213 | AWAT2, i.e. DC4; X-linked genes AWAT1/DGA2 and AWAT2/DC4 | - |
Homo sapiens | Q6E213 | gene DGAT2L4; isozyme DC4 or AWAT2 | - |
Homo sapiens | Q6ZPD8 | gene DGAT2L6; isozyme DC3 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | tissue distribution of DC3 expression, overview | Homo sapiens | - |
additional information | tissue distribution of DC4 expression, overview | Homo sapiens | - |
additional information | tissue distribution of DGA2 expression, overview | Homo sapiens | - |
skin | predominant expression | Homo sapiens | - |
skin | predominant expression of AWAT1 | Homo sapiens | - |
skin | predominant expression of AWAT2 | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
additional information | - |
substrate specificity, overview | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + long-chain diacylglycerol | - |
Homo sapiens | CoA + long-chain triacylglycerol | - |
? | |
acyl-CoA + long-chain fatty alcohol | - |
Homo sapiens | CoA + long-chain fatty ester | - |
? | |
cetyl alcohol + oleoyl-CoA | - |
Homo sapiens | CoA + cetyloleate | - |
? | |
linear long-chain alcohol + oleoyl-CoA | - |
Homo sapiens | ? | - |
? | |
linear long-chain alcohol + palmitoleoyl-CoA | - |
Homo sapiens | ? | - |
? | |
linear long-chain alcohol + palmitoyl-CoA | - |
Homo sapiens | ? | - |
? | |
linear long-chain alcohol + stearoyl-CoA | - |
Homo sapiens | ? | - |
? | |
additional information | AWAT 1 predominantly esterifies long chain, wax alcohols with acyl-CoA-derived fatty acids to produce wax esters, AWAT1 and AWAT2 have very distinct substrate preferences in terms of alcohol chain length and fatty acyl saturation, overview | Homo sapiens | ? | - |
? | |
additional information | AWAT 2 predominantly esterifies long chain, wax alcohols with acyl-CoA-derived fatty acids to produce wax esters, AWAT1 and AWAT2 have very distinct substrate preferences in terms of alcohol chain length and fatty acyl saturation, overview, no activity of AWAT2 with 1-decanol | Homo sapiens | ? | - |
? | |
additional information | bifunctional enzyme also catalyzing the reaction of EC 2.3.1.20 | Homo sapiens | ? | - |
? | |
additional information | substrate specificity of AWAT1, overview, AWAT1 and AWAT2 have very distinct substrate preferences in terms of alcohol chain length and fatty acyl saturation and predominantly esterify long chain alcohols with acyl-CoA-derived fatty acids to produce wax esters, bifunctional enzyme also catalyzing the reaction of EC 2.3.1.20 | Homo sapiens | ? | - |
? | |
additional information | substrate specificity of AWAT2, overview, AWAT1 and AWAT2 have very distinct substrate preferences in terms of alcohol chain length and fatty acyl saturation and predominantly esterify long chain alcohols with acyl-CoA-derived fatty acids to produce wax esters, bifunctional enzyme also catalyzing the reaction of EC 2.3.1.20 | Homo sapiens | ? | - |
? | |
oleoyl-CoA + (9Z)-hexadec-9-en-1-ol | - |
Homo sapiens | CoA + (9Z)-hexadec-9-en-1-yl (9Z)-octadec-9-enoate | - |
? | |
oleoyl-CoA + 1-decanol | - |
Homo sapiens | CoA + decyl oleate | - |
? | |
oleoyl-CoA + 1-octadecanol | - |
Homo sapiens | CoA + octadecyl oleate | - |
? | |
oleoyl-CoA + cetyl alcohol | - |
Homo sapiens | CoA + cetyl oleate | - |
? | |
oleoyl-CoA + decanol | - |
Homo sapiens | CoA + decyl oleate | - |
? | |
oleoyl-CoA + eicosanol | - |
Homo sapiens | CoA + icosyl (9Z)-octadec-9-enoate | - |
? | |
oleoyl-CoA + oleic alcohol | - |
Homo sapiens | CoA + (9Z)-octadec-9-en-1-yl (9Z)-octadec-9-enoate | - |
? | |
palmitoleoyl-CoA + cetyl alcohol | - |
Homo sapiens | CoA + cetyl palmitoleate | - |
? | |
palmitoleyl alcohol + oleoyl-CoA | - |
Homo sapiens | CoA + palmitoleyl oleate | - |
? | |
palmitoyl-CoA + cetyl alcohol | - |
Homo sapiens | CoA + cetyl palmitate | - |
? | |
stearoyl-CoA + cetyl alcohol | - |
Homo sapiens | CoA + cetyl stearate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acyl-CoA wax alcohol acyltransferase | - |
Homo sapiens |
acyl-CoA wax alcohol acyltransferases | - |
Homo sapiens |
AWAT | - |
Homo sapiens |
AWAT 1 | - |
Homo sapiens |
AWAT 2 | - |
Homo sapiens |
More | cf. EC 2.3.1.20, the enzyme belongs to the acyl-CoA:diacylglycerol acyltransferase, DGAT, 2 gene superfamily | Homo sapiens |
More | the enzyme belongs to the diacylglycerol acyltransferase 2, DGAT2, gene superfamily, cf. EC 2.3.1.20 | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |