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Literature summary for 2.3.1.74 extracted from

  • Martin, C.R.
    Structure, function, and regulation of the chalcone synthase (1993), Int. Rev. Cytol., 147, 233-284.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
apigenin
-
Secale cereale
CoA 50% inhibition at 0.01 mM Petroselinum crispum
CoA
-
Secale cereale
Kievitone
-
Phaseolus vulgaris
luteolin
-
Secale cereale
naringenin 50% inhibition at 0.01 mM Petroselinum crispum
naringenin
-
Phaseolus vulgaris
naringenin 0.1 mM Secale cereale
naringenin chalcone
-
Daucus carota
naringenin chalcone 0.1 mM Secale cereale

Organism

Organism UniProt Comment Textmining
Daucus carota
-
-
-
Petroselinum crispum
-
-
-
Phaseolus vulgaris
-
-
-
Pinus sylvestris
-
Scots pine
-
Secale cereale
-
-
-
Silene sp.
-
-
-
Sinapis alba
-
white mustard
-
Verbena sp.
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
caffeoyl-CoA + 3 malonyl-CoA
-
Daucus carota eriodictyol + 4 CoA + 3 CO2
-
?
caffeoyl-CoA + 3 malonyl-CoA
-
Secale cereale eriodictyol + 4 CoA + 3 CO2
-
?
caffeoyl-CoA + 3 malonyl-CoA
-
Silene sp. eriodictyol + 4 CoA + 3 CO2
-
?
caffeoyl-CoA + 3 malonyl-CoA less efficient than 4-coumaroyl-CoA Verbena sp. eriodictyol + 4 CoA + 3 CO2
-
?
cinnamoyl-CoA + malonyl-CoA
-
Sinapis alba 5,7-dihydroxyflavanone + CoA + CO2
-
?
cinnamoyl-CoA + malonyl-CoA
-
Pinus sylvestris 5,7-dihydroxyflavanone + CoA + CO2 i.e. pinocembrin ?
malonyl-CoA + 4-coumaroyl-CoA
-
Phaseolus vulgaris naringenin chalcone + CoA + CO2
-
?
malonyl-CoA + 4-coumaroyl-CoA
-
Petroselinum crispum naringenin chalcone + CoA + CO2
-
?
malonyl-CoA + 4-coumaroyl-CoA
-
Daucus carota naringenin chalcone + CoA + CO2
-
?
malonyl-CoA + 4-coumaroyl-CoA
-
Secale cereale naringenin chalcone + CoA + CO2
-
?
malonyl-CoA + 4-coumaroyl-CoA
-
Silene sp. naringenin chalcone + CoA + CO2
-
?
malonyl-CoA + 4-coumaroyl-CoA
-
Verbena sp. naringenin chalcone + CoA + CO2
-
?