Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | isoforms Yat1 and Yat2 | Candida albicans | 5829 | - |
mitochondrion | isoform Cat2 | Candida albicans | 5739 | - |
peroxisome | isoform Cat2 | Candida albicans | 5777 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida albicans | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
CAT2 | - |
Candida albicans |
Yat1 | - |
Candida albicans |
General Information | Comment | Organism |
---|---|---|
physiological function | carnitine acetyltransferase Yat1 is cytosolic and contributes to acetyl-CoA transport from the cytosol during growth on ethanol or acetate, but its activity is not required for growth on oleate | Candida albicans |
physiological function | mitochondrial carnitine acetyltransferase Cat2 is required for the intramitochondrial conversion of acetylcarnitine to acetyl-CoA, which is essential for a functional tricarboxylic acid cycle during growth on oleate, acetate, ethanol, and citrate. Peroxisomal Cat2 is essential neither for export of acetyl units during growth on oleate nor for the import of acetyl units during growth on acetate or ethanol. Oxidation of fatty acids still takes place in the absence of peroxisomal Cat2, but biomass formation is absent, and the strain displays a growth delay on acetate and ethanol that can be partially rescued by the addition of carnitine | Candida albicans |