Any feedback?
Literature summary for 2.3.1.7 extracted from
- Isolation and characterization of carnitine acetyltransferase from S. cerevisiae (1991), Biochim. Biophys. Acta, 1085, 217-222.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0177 | - |
acetyl-CoA | - |
Saccharomyces cerevisiae |  |
| 0.076 | - |
acetyl-CoA | - |
Saccharomyces cerevisiae | |
| 0.17 | - |
L-(-)-carnitine | - |
Saccharomyces cerevisiae | |
| 0.23 | - |
L-(-)-carnitine | - |
Saccharomyces cerevisiae | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrial matrix | - |
Rattus norvegicus | 5759 | - |
| mitochondrial matrix | - |
Saccharomyces cerevisiae | 5759 | - |
| mitochondrial matrix | - |
Candida tropicalis | 5759 | - |
| mitochondrial matrix | - |
Torulopsis bovina | 5759 | - |
| mitochondrion | - |
Homo sapiens | 5739 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
| mitochondrion | - |
Candida tropicalis | 5739 | - |
| mitochondrion | - |
Torulopsis bovina | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 65000 | - |
6 * 65000, SDS-PAGE | Saccharomyces cerevisiae |
| 400000 | - |
- |
Saccharomyces cerevisiae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + carnitine | Homo sapiens | - |
O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | Rattus norvegicus | - |
O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | Saccharomyces cerevisiae | - |
O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | Bos taurus | - |
O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | Candida tropicalis | - |
O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | Columba sp. | - |
O-acetylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | Homo sapiens | - |
acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | Rattus norvegicus | - |
acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | Saccharomyces cerevisiae | - |
acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | Bos taurus | - |
acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | Candida tropicalis | - |
acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | Columba sp. | - |
acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | Torulopsis bovina | - |
acylcarnitine + CoASH | - |
r | |
| acylcarnitine + CoASH | Homo sapiens | - |
acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | Rattus norvegicus | - |
acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | Saccharomyces cerevisiae | - |
acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | Bos taurus | - |
acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | Candida tropicalis | - |
acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | Columba sp. | - |
acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | Torulopsis bovina | - |
acyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | Homo sapiens | - |
acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | Rattus norvegicus | - |
acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | Bos taurus | - |
acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | Candida tropicalis | - |
acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | Columba sp. | - |
acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | Saccharomyces cerevisiae | acetate metabolism, enzyme transports activated acetyl group from the cytosol into the mitochondrial matrix | acetyl-CoA + carnitine | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
bovine | - |
| Candida tropicalis | - |
yeast | - |
| Columba sp. | - |
pigeon | - |
| Homo sapiens | - |
human | - |
| Rattus norvegicus | - |
rat | - |
| Saccharomyces cerevisiae | - |
baker's yeast | - |
| Torulopsis bovina | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Saccharomyces cerevisiae |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast muscle | - |
Columba sp. | - |
| brown adipose tissue | - |
Rattus norvegicus | - |
| heart | - |
Homo sapiens | - |
| heart | - |
Rattus norvegicus | - |
| heart | - |
Bos taurus | - |
| heart | - |
Columba sp. | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Columba sp. | - |
| muscle | - |
Rattus norvegicus | - |
| muscle | - |
Columba sp. | - |
| semen | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 200 | - |
- |
Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + carnitine | - |
Homo sapiens | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | - |
Rattus norvegicus | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | - |
Saccharomyces cerevisiae | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | - |
Bos taurus | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | - |
Candida tropicalis | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | - |
Columba sp. | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + L-(-)carnitine | - |
Homo sapiens | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + L-(-)carnitine | - |
Rattus norvegicus | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + L-(-)carnitine | - |
Saccharomyces cerevisiae | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + L-(-)carnitine | - |
Bos taurus | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + L-(-)carnitine | - |
Candida tropicalis | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + L-(-)carnitine | - |
Columba sp. | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + L-(-)carnitine | - |
Torulopsis bovina | O-acetylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | - |
Homo sapiens | acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | - |
Rattus norvegicus | acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | - |
Saccharomyces cerevisiae | acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | - |
Bos taurus | acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | - |
Candida tropicalis | acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | - |
Columba sp. | acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | - |
Torulopsis bovina | acylcarnitine + CoASH | - |
r | |
| acylcarnitine + CoASH | - |
Homo sapiens | acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | - |
Rattus norvegicus | acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | - |
Saccharomyces cerevisiae | acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | - |
Bos taurus | acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | - |
Candida tropicalis | acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | - |
Columba sp. | acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | - |
Torulopsis bovina | acyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Homo sapiens | acetyl-CoA + L-(-)carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Rattus norvegicus | acetyl-CoA + L-(-)carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Saccharomyces cerevisiae | acetyl-CoA + L-(-)carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Bos taurus | acetyl-CoA + L-(-)carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Candida tropicalis | acetyl-CoA + L-(-)carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Columba sp. | acetyl-CoA + L-(-)carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Torulopsis bovina | acetyl-CoA + L-(-)carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Homo sapiens | acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Rattus norvegicus | acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Bos taurus | acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Candida tropicalis | acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Columba sp. | acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | acetate metabolism, enzyme transports activated acetyl group from the cytosol into the mitochondrial matrix | Saccharomyces cerevisiae | acetyl-CoA + carnitine | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| hexamer | 6 * 65000, SDS-PAGE | Saccharomyces cerevisiae |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8 | - |
Saccharomyces cerevisiae |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 9 | - |
Saccharomyces cerevisiae |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 9 | below pH 6.0 enzyme undergoes irreversible inactivation | Saccharomyces cerevisiae |
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