General Stability | Organism |
---|---|
enzyme is stable throughout purification procedure | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-hydroxynonenal | - |
Rattus norvegicus | |
iodoacetic acid | - |
Rattus norvegicus | |
p-chloromercuriphenyl sulfonic acid | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.022 | - |
CoASH | substrate hexanoylcarnitine, enzyme from liver homogenate | Rattus norvegicus | |
0.024 | - |
CoASH | substrate decanoylcarnitine, enzyme from liver homogenate | Rattus norvegicus | |
0.027 | - |
CoASH | substrate decanoylcarnitine, enzyme from mitochondria | Rattus norvegicus | |
0.027 | - |
CoASH | substrate butyrylcarnitine and octanoylcarnitine, enzyme from liver homogenate | Rattus norvegicus | |
0.028 | - |
CoASH | substrate acetylcarnitine, enzyme from liver homogenate | Rattus norvegicus | |
0.032 | - |
CoASH | substrate acetylcarnitine, enzyme from mitochondria | Rattus norvegicus | |
0.038 | - |
CoASH | substrate butyrylcarnitine, enzyme from mitochondria | Rattus norvegicus | |
0.044 | - |
CoASH | substrate hexanoylcarnitine, enzyme from mitochondria | Rattus norvegicus | |
0.054 | - |
CoASH | substrate octanoylcarnitine, enzyme from mitochondria | Rattus norvegicus | |
0.39 | - |
acetylcarnitine | enzyme from liver homogenate | Rattus norvegicus | |
0.48 | - |
butyrylcarnitine | enzyme from liver homogenate | Rattus norvegicus | |
0.6 | - |
acetylcarnitine | enzyme from mitochondria | Rattus norvegicus | |
0.64 | - |
decanoylcarnitine | enzyme from mitochondria | Rattus norvegicus | |
0.66 | - |
decanoylcarnitine | enzyme from liver homogenate | Rattus norvegicus | |
0.66 | - |
butyrylcarnitine | enzyme from mitochondria | Rattus norvegicus | |
1.27 | - |
octanoylcarnitine | enzyme from mitochondria | Rattus norvegicus | |
1.62 | - |
octanoylcarnitine | enzyme from liver homogenate | Rattus norvegicus | |
2.28 | - |
hexanoylcarnitine | enzyme from liver homogenate | Rattus norvegicus | |
2.51 | - |
hexanoylcarnitine | enzyme from mitochondria | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
peroxisome | - |
Rattus norvegicus | 5777 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
25000 | - |
1 * 34000 + 1 * 25000, purified from mitochondrial fraction of liver, rats fed on a diet containing ethyl p-chlorophenoxyisobutyrate, SDS-PAGE | Rattus norvegicus |
27000 | - |
1 * 36500 + 1 * 27000, purified from mitochondrial fraction, monomeric form converted into dimeric by proteolytic modification after disruption of mitochondria, SDS-PAGE | Rattus norvegicus |
34000 | - |
1 * 34000 + 1 * 25000, purified from mitochondrial fraction of liver, rats fed on a diet containing ethyl p-chlorophenoxyisobutyrate, SDS-PAGE | Rattus norvegicus |
36500 | - |
1 * 36500 + 1 * 27000, purified from mitochondrial fraction, monomeric form converted into dimeric by proteolytic modification after disruption of mitochondria, SDS-PAGE | Rattus norvegicus |
56000 | - |
purified from mitochondrial fraction of liver, rats fed on a diet containing ethyl p-chlorophenoxyisobutyrate | Rattus norvegicus |
61900 | - |
purified from mitochondrial fraction, gel filtration | Rattus norvegicus |
66100 | - |
purified from liver homogenate, gel filtration | Rattus norvegicus |
67500 | - |
purified from liver homogenate, SDS-PAGE | Rattus norvegicus |
69000 | - |
translation product of the enzyme by the reticulocyte lysate protein-synthesizing system | Rattus norvegicus |
69000 | - |
post-mitochondrial fraction, 2 polypeptides 67500 Da + 69000 Da cannot be separated from each other | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + carnitine | Rattus norvegicus | - |
O-acetylcarnitine + CoASH | - |
r | |
acetyl-CoA + carnitine | Columba sp. | - |
O-acetylcarnitine + CoASH | - |
r | |
acyl-CoA + carnitine | Rattus norvegicus | - |
acylcarnitine + CoASH | - |
r | |
acyl-CoA + carnitine | Columba sp. | - |
acylcarnitine + CoASH | - |
r | |
acylcarnitine + CoASH | Rattus norvegicus | - |
acyl-CoA + carnitine | - |
r | |
acylcarnitine + CoASH | Columba sp. | - |
acyl-CoA + carnitine | - |
r | |
O-acetylcarnitine + CoASH | Rattus norvegicus | - |
acetyl-CoA + carnitine | - |
r | |
O-acetylcarnitine + CoASH | Columba sp. | - |
acetyl-CoA + carnitine | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Columba sp. | - |
pigeon | - |
Rattus norvegicus | - |
rat | - |
Purification (Comment) | Organism |
---|---|
purified from mitochondrial fraction and from homogenate of frozen liver | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
liver | - |
Columba sp. | - |
muscle | - |
Rattus norvegicus | - |
muscle | - |
Columba sp. | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
120 | - |
purified from postmitochondrial fraction | Rattus norvegicus |
220 | - |
purified from liver homogenate | Rattus norvegicus |
240 | - |
purified from mitochondrial fraction | Rattus norvegicus |
Storage Stability | Organism |
---|---|
-20°C, 50 mM potassium phosphate buffer, pH 7.5, purified enzyme can be stored for several months without loss of activity | Rattus norvegicus |
-20°C, frozen mitochondrial fraction can be stored for several months without loss of activity | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + carnitine | - |
Rattus norvegicus | O-acetylcarnitine + CoASH | - |
r | |
acetyl-CoA + carnitine | - |
Columba sp. | O-acetylcarnitine + CoASH | - |
r | |
acetyl-CoA + L-(-)carnitine | - |
Rattus norvegicus | O-acetylcarnitine + CoASH | - |
r | |
acetyl-CoA + L-(-)carnitine | - |
Columba sp. | O-acetylcarnitine + CoASH | - |
r | |
acyl-CoA + carnitine | - |
Rattus norvegicus | acylcarnitine + CoASH | - |
r | |
acyl-CoA + carnitine | - |
Columba sp. | acylcarnitine + CoASH | - |
r | |
acylcarnitine + CoASH | - |
Rattus norvegicus | acyl-CoA + carnitine | - |
r | |
acylcarnitine + CoASH | - |
Columba sp. | acyl-CoA + carnitine | - |
r | |
decanoyl-CoA + carnitine | - |
Rattus norvegicus | decanoylcarnitine + CoASH | - |
r | |
decanoyl-CoA + carnitine | - |
Columba sp. | decanoylcarnitine + CoASH | - |
r | |
decanoylcarnitine + CoASH | - |
Rattus norvegicus | decanoyl-CoA + carnitine | - |
r | |
decanoylcarnitine + CoASH | - |
Columba sp. | decanoyl-CoA + carnitine | - |
r | |
hexanoyl-CoA + carnitine | - |
Rattus norvegicus | hexanoylcarnitine + CoASH | - |
r | |
hexanoyl-CoA + carnitine | - |
Columba sp. | hexanoylcarnitine + CoASH | - |
r | |
hexanoylcarnitine + CoASH | - |
Rattus norvegicus | hexanoyl-CoA + carnitine | - |
r | |
hexanoylcarnitine + CoASH | - |
Columba sp. | hexanoyl-CoA + carnitine | - |
r | |
n-butyryl-CoA + carnitine | - |
Rattus norvegicus | n-butyrylcarnitine + CoASH | - |
r | |
n-butyrylcarnitine + CoASH | - |
Rattus norvegicus | n-butyryl-CoA + carnitine | - |
r | |
O-acetylcarnitine + CoASH | - |
Rattus norvegicus | acetyl-CoA + L-(-)carnitine | - |
r | |
O-acetylcarnitine + CoASH | - |
Columba sp. | acetyl-CoA + L-(-)carnitine | - |
r | |
O-acetylcarnitine + CoASH | - |
Rattus norvegicus | acetyl-CoA + carnitine | - |
r | |
O-acetylcarnitine + CoASH | - |
Columba sp. | acetyl-CoA + carnitine | - |
r | |
octanoyl-CoA + carnitine | - |
Rattus norvegicus | octanoylcarnitine + CoASH | - |
r | |
octanoylcarnitine + CoASH | - |
Rattus norvegicus | octanoyl-CoA + carnitine | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | 1 * 36500 + 1 * 27000, purified from mitochondrial fraction, monomeric form converted into dimeric by proteolytic modification after disruption of mitochondria, SDS-PAGE | Rattus norvegicus |
dimer | 1 * 34000 + 1 * 25000, purified from mitochondrial fraction of liver, rats fed on a diet containing ethyl p-chlorophenoxyisobutyrate, SDS-PAGE | Rattus norvegicus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
4 | 25 | stored in a refrigerator for 2 days or incubated at 25°C for 5 h, monomeric form remains unchanged | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Rattus norvegicus |