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Literature summary for 2.3.1.67 extracted from

  • Morimoto, R.; Shindou, H.; Tarui, M.; Shimizu, T.
    Rapid production of platelet-activating factor is induced by protein kinase Calpha-mediated phosphorylation of lysophosphatidylcholine acyltransferase 2 protein (2014), J. Biol. Chem., 289, 15566-15576.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme is rapidly phosphorylated after methylcarbamylplatelet-activating factor stimulation to enhance its enzymatic activity. Knockdown of PKCalpha results in significant decrease of lyso-PAFAT activation after ATP stimulation Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
stable recombinant enzyme expression in RAW264.7 cells, recombinant expression in CHO-S-PAFR cells Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine Mus musculus
-
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
?
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine Mus musculus C57/BL6J
-
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
?
additional information Mus musculus LPCAT2 also possesses lysophosphatidylcholine acyltransferase, EC: 2.3.1.23, activity that catalyzes the incorporation of arachidonoyl-CoA into membrane phosphatidylcholine ?
-
?
additional information Mus musculus C57/BL6J LPCAT2 also possesses lysophosphatidylcholine acyltransferase, EC: 2.3.1.23, activity that catalyzes the incorporation of arachidonoyl-CoA into membrane phosphatidylcholine ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8BYI6
-
-
Mus musculus C57/BL6J Q8BYI6
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein stimulation by either platelet-activating factor or ATP results in PKCalpha-mediated phosphorylation of the enzyme at Ser34 causing augmentation of Vmax with minimal Km change. The enzyme is rapidly phosphorylated after methylcarbamylplatelet-activating factor stimulation to enhance its enzymatic activity Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine
-
Mus musculus CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
?
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine
-
Mus musculus C57/BL6J CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
?
additional information LPCAT2 also possesses lysophosphatidylcholine acyltransferase, EC: 2.3.1.23, activity that catalyzes the incorporation of arachidonoyl-CoA into membrane phosphatidylcholine Mus musculus ?
-
?
additional information LPCAT2 also possesses lysophosphatidylcholine acyltransferase, EC: 2.3.1.23, activity that catalyzes the incorporation of arachidonoyl-CoA into membrane phosphatidylcholine Mus musculus C57/BL6J ?
-
?

Synonyms

Synonyms Comment Organism
acetyl-CoA:lyso-PAF acetyltransferase
-
Mus musculus
LPCAT2
-
Mus musculus
lyso-PAFAT
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
Mus musculus

General Information

General Information Comment Organism
metabolism platelet-activating factor is synthesized rapidly in the remodeling pathway from its precursor membrane phospholipid, 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine, involving the enzyme Mus musculus
physiological function platelet-activating factor (PAF), a potent proinflammatory lipid mediator, is synthesized rapidly in response to extracellular stimuli by the activation of acetyl-CoA:lyso-PAF acetyltransferase, lyso-PAFAT. The enzyme is rapidly phosphorylated after methylcarbamylplatelet-activating factor stimulation to enhance its enzymatic activity Mus musculus