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Literature summary for 2.3.1.67 extracted from
- Substrate specificities of neuronal nuclear acetyltransferases involved in the synthesis of platelet-activating factor: Differences in the use of 1-alkyl and 1-acyl lysophospholipid acceptors (1998), Biochim. Biophys. Acta, 1390, 215-224.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-acyl-sn-glycero-3-phosphate | competitive inhibition for 1-alkyl-sn-glycero-3-phosphate | Oryctolagus cuniculus |  |
| oleic acid | 1-acyl lysolipids less inhibited than the 1-alkyl species | Oryctolagus cuniculus | |
| oleoyl-CoA | 45-55% inhibition | Oryctolagus cuniculus | |
| serine/threonine phosphatase | diminishes rates of acetylation for 1-alkyl-sn-glycero-3-phosphocholine and 1-acyl-sn-glycero-3-phosphocholine | Oryctolagus cuniculus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.009 | - |
1-O-alkyl-sn-glycero-3-phosphate | - |
Oryctolagus cuniculus | |
| 0.011 | - |
1-acyl-sn-glycero-3-phosphate | - |
Oryctolagus cuniculus | |
| 0.018 | - |
1-alkyl-sn-glycero-3-phosphocholine | - |
Oryctolagus cuniculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Oryctolagus cuniculus | 5634 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cerebral cortex | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + 1-acyl-sn-glycero-3-phosphate | - |
Oryctolagus cuniculus | CoA + 2-acetyl-1-acyl-sn-glycero-3-phosphate | - |
? | |
| acetyl-CoA + 1-acyl-sn-glycero-3-phosphocholine | - |
Oryctolagus cuniculus | CoA + 2-acetyl-1-acyl-sn-glycero-3-phosphocholine | - |
? | |
| acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine | - |
Oryctolagus cuniculus | CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine | - |
? | |
| acetyl-CoA + 1-O-alkyl-sn-glycero-3-phosphate | - |
Oryctolagus cuniculus | CoA + 2-acetyl-1-alkyl-6-phosphate | - |
? | |
| acetyl-CoA + alkyl-sn-glycero-3-phosphocholine | - |
Oryctolagus cuniculus | CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Oryctolagus cuniculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.4 | - |
assay at | Oryctolagus cuniculus |
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Release 2023.1 (January 2023)
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