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Literature summary for 2.3.1.65 extracted from

  • Ide, T.; Kano, S.; Murata, M.; Yanagita, T.; Sugano, M.
    Dietary modifications of the biliary bile acid glycine:taurine ratio and activity of hepatic bile acid-CoA:amino acid N-acyltransferase (EC 2.3.1) in the rat (1994), Br. J. Nutr., 72, 93-100.
    View publication on PubMed
Search for more literature for 2.3.1.65

Activating Compound

Activating Compound Comment Organism Structure
Pectin dietary pectin relative to cellulose activates, especially the glycine-dependent activity Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.8 2.5 taurine
-
 Rattus norvegicus
0.83
-
 taurine rats fed with cellulose Rattus norvegicus
1.02
-
 taurine rats fed with pectin Rattus norvegicus
35 40 glycine
-
 Rattus norvegicus
38
-
 glycine rats fed with cellulose Rattus norvegicus
40
-
 glycine rats fed with pectin Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information in the post-mitochondrial fraction of liver homogenates Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
choloyl-CoA + taurine Rattus norvegicus taurine conjugates predominate in rat bile at normal hepatocellular concentrations of glycine and taurine CoA + taurocholate
-
 ?
choloyl-CoA + taurine Rattus norvegicus bile acid conjugation CoA + taurocholate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male Wistar rats, 4 weeks old
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
choloyl-CoA + glycine produces taurine- but little glycine-conjugated bile acid at physiological concentrations of glycine and taurine, dietary manipulations modify the glycine:taurine ratio Rattus norvegicus CoA + glycocholate
-
 ?
choloyl-CoA + taurine produces taurine- but little glycine-conjugated bile acid at physiological concentrations of glycine and taurine, dietary manipulations modify the hepatic taurine concentration and glycine:taurine ratio Rattus norvegicus CoA + taurocholate
-
 ?
choloyl-CoA + taurine taurine conjugates predominate in rat bile at normal hepatocellular concentrations of glycine and taurine Rattus norvegicus CoA + taurocholate
-
 ?
choloyl-CoA + taurine bile acid conjugation Rattus norvegicus CoA + taurocholate
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus