Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
male transgenic Tg19959 mice (model of amyloid deposition, 2 mutations in the human amyloid precursor protein) are crossed with dihydrolipoyl succinyltransferase deficient female mice (DLST+/-) | - |
Synonyms | Comment | Organism |
---|---|---|
dihydrolipoyl succinyltransferase | - |
Homo sapiens |
DLST | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | reduced enzyme activity increases H2O2-induced reactive oxygen species production and cell death, in human Alzheimer disease brains the activity of the alpha-ketoglutarate dehydrogenase enzyme complex is reduced, enzyme deficient mice show increased plaque burden, Abeta oligomers, and nitrotyrosine levels, the occurrence of spatial learning and memory deficits in female Tg19959 mice is accelerated | Homo sapiens |
physiological function | key subunit of the alpha-ketoglutarate dehydrogenase enzyme complex, involved in NADH production, participation in oxidative stress and reactive oxygen species (ROS) production | Homo sapiens |