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Literature summary for 2.3.1.61 extracted from

  • MacDonald, M.J.; Husain, R.D.; Hoffmann-Benning, S.; Baker, T.R.
    Immunochemical identification of coenzyme Q0-dihydrolipoamide adducts in the E2 components of the alpha-ketoglutarate and pyruvate dehydrogenase complexes partially explains the cellular toxicity of coenzyme Q0 (2004), J. Biol. Chem., 279, 27278-27285.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
coenzyme Q0 formation of coenzyme Q0-dihydrolipoamide adducts in the E2 components of the alpha-ketoglutarate complex (i.e. dihydrolipoamide succinyltransferase) partially explains the cellular toxicity of coenzyme Q0 Homo sapiens
coenzyme Q0 formation of coenzyme Q0-dihydrolipoamide adducts in the E2 components of the alpha-ketoglutarate complex (i.e. dihydrolipoamide succinyltransferase) partially explains the cellular toxicity of coenzyme Q0 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-
mitochondrion
-
Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
x * 50000, SDS-PAGE Homo sapiens
50000
-
x * 50000, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Rattus norvegicus
-
brain
-
Rattus norvegicus
-
heart
-
Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
lung
-
Rattus norvegicus
-
pancreatic islet
-
Homo sapiens
-
pancreatic islet
-
Rattus norvegicus
-
skeletal muscle
-
Rattus norvegicus
-
spleen
-
Rattus norvegicus
-

Subunits

Subunits Comment Organism
? x * 50000, SDS-PAGE Homo sapiens
? x * 50000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
dihydrolipoamide succinyltransferase
-
Homo sapiens
dihydrolipoamide succinyltransferase
-
Rattus norvegicus
E2 component of alpha-ketoglutarate dehydrogenase complex
-
Homo sapiens
E2 component of alpha-ketoglutarate dehydrogenase complex
-
Rattus norvegicus