Literature summary for 2.3.1.6 extracted from

Saito, A.; Sato, T.; Okano, H.; Toyoda, K.; Bamba, H.; Kimura, S.; Bellier, J.P.; Matsuo, A.; Kimura, H.; Hisa, Y.; Tooyama, I.
Axotomy alters alternative splicing of choline acetyltransferase in the rat dorsal motor nucleus of the vagus nerve (2009), J. Comp. Neurol., 513, 237-248.

Search for more literature for 2.3.1.6

Cloned(Commentary)

Cloned (Comment)	Organism
cDNAs encoding splicing variants cChAT and pChAT, purified from the rat striatum and pterygopalatine ganglion, respectively, expression analysis. Recombinant expression in HEK-293 cells	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acetyl-CoA + choline	Rattus norvegicus	-	CoA + O-acetylcholine	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	two splicing variants, peripheral-type pChAT and common-type cChAT	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	cChAT and pChAt expression analysis in brain, overview	Rattus norvegicus	-
additional information	after axotomy pChAT immunoreactivity is apparent in some brainstem nuclei, such as the dorsal motor nucleus of the vagus nerve, the nucleus ambiguus, and the hypoglossal nucleus, but not in the brainstem neurons of normal rats	Rattus norvegicus	-
vagus nerve	dorsal motor nucleus of the vagus nerve, contains a peripheral-type pChAT, a splice variant that lacks exons 6-9 of the common-type ChAT, cChAT	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + choline	-	Rattus norvegicus	CoA + O-acetylcholine	-	?

Synonyms

Synonyms	Comment	Organism
ChAT	-	Rattus norvegicus
choline acetyltransferase	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
acetyl-CoA	-	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	pChAT expression is induced by neuronal damage	up

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Release 2023.1 (January 2023)