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Literature summary for 2.3.1.6 extracted from

  • Tateno, M.; Kato, S.; Sakurai, T.; Nukina, N.; Takahashi, R.; Araki, T.
    Mutant SOD1 impairs axonal transport of choline acetyltransferase and acetylcholine release by sequestering KAP3 (2009), Hum. Mol. Genet., 18, 942-955.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
kinesin-associated protein 3 i.e. KAP3, is a kinesin-2 subunit responsible for binding to cargos including choline acetyltransferase. Sequestration by misfolded SOD1 species results in inhibition of ChAT transport Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microtubule ChAT transport in the microtubule, schematic overview Mus musculus 5874
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Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
NG-108-15 cell
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Mus musculus
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spinal cord motor neurons Mus musculus
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Synonyms

Synonyms Comment Organism
ChAT
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Mus musculus
choline acetyltransferase
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Mus musculus

General Information

General Information Comment Organism
malfunction mutations in the superoxide dismutase 1, sod1, gene cause familial amyotrophic lateral sclerosis and motor axons in SOD1G93A-Tg mice also show a reduction in ChAT transport from the pre-onset stage, microtubule-dependent release of acetylcholine is significantly impaired by misfolded SOD1 species, overview. Sequestration by misfolded SOD1 species results in inhibition of ChAT transport, which plays a role in amyotrophic lateral sclerosis, overview Mus musculus