Activating Compound | Comment | Organism | Structure |
---|---|---|---|
kinesin-associated protein 3 | i.e. KAP3, is a kinesin-2 subunit responsible for binding to cargos including choline acetyltransferase. Sequestration by misfolded SOD1 species results in inhibition of ChAT transport | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microtubule | ChAT transport in the microtubule, schematic overview | Mus musculus | 5874 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
NG-108-15 cell | - |
Mus musculus | - |
spinal cord | motor neurons | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
ChAT | - |
Mus musculus |
choline acetyltransferase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | mutations in the superoxide dismutase 1, sod1, gene cause familial amyotrophic lateral sclerosis and motor axons in SOD1G93A-Tg mice also show a reduction in ChAT transport from the pre-onset stage, microtubule-dependent release of acetylcholine is significantly impaired by misfolded SOD1 species, overview. Sequestration by misfolded SOD1 species results in inhibition of ChAT transport, which plays a role in amyotrophic lateral sclerosis, overview | Mus musculus |