Application | Comment | Organism |
---|---|---|
diagnostics | ChAT is selected as a marker of cholinergicneurons. In the CA1 region of hippocampus of mice, several of the insulin signaling-related proteins are co-located with ChAT, and most double immunoreactive positive cells are pyramidal cells | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Mus musculus | 5737 | - |
additional information | immunofluorescent localization study, overview | Mus musculus | - |
- |
nucleus | - |
Mus musculus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + choline | Mus musculus | - |
CoA + O-acetylcholine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hippocampus | cholinergic neuron-specific ChAT in the CA1 region of hippocampus | Mus musculus | - |
additional information | immunofluorescent localization study, overview | Mus musculus | - |
neuron | - |
Mus musculus | - |
pyramidal cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + choline | - |
Mus musculus | CoA + O-acetylcholine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ChAT | - |
Mus musculus |
choline acetyltransferase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | ChAT is the rate-limiting enzyme of generating acetylcholine, which is synthesized in cholinergic neuronal cell bodies. Insulin signaling may play an important part in the activities of cholinergic neurons | Mus musculus |