Cloned (Comment) | Organism |
---|---|
recombinant overexpression of the enzyme in enzyme-deficient and wild-type mice using the endogenous enzyme promoter, quantitative PCR expression analysis | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P48026 | - |
- |
Mus musculus C57BL/6JOlaHsd | P48026 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mesenchymal stromal cell | - |
Mus musculus | - |
osteoblast | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
spermidine/spermine N1-acetyltransferase | - |
Mus musculus |
SSAT | - |
Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | induction of enzyme SSAT with alpha-methylspermidine disturbs wild-type osteoblastogenesis | up |
General Information | Comment | Organism |
---|---|---|
malfunction | body weights, femur and tibia lengths and diameters, and ash weights of tibia of wild-type, SSAT overexpressing, and SSAT deficient female mice, overview. Enzyme overexpressing SSAT mice have an altered skeletal appearance with increased collagen cleavage and reduced bone strength compared to the wild-type. Engineered mice also show altered differentiation of mesenchymal stromal cells to osteoblasts. Polyamine metabolism of SSAT osteoblasts is disturbed. Osteoblasts of SSAT overexpressing mice show significantly increased SSAT enzyme activity | Mus musculus |
physiological function | spermidine/spermine N1-acetyltransferase is a catabolic regulator of polyamines, ubiquitous molecules essential for cell proliferation and differentiation. Role of polyamine metabolism in bone remodeling | Mus musculus |