Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.57 extracted from

  • Neidhart, M.; Karouzakis, E.; Juengel, A.; Gay, R.E.; Gay, S.
    Inhibition of spermidine/spermine N1-acetyltransferase activity: a new therapeutic concept in rheumatoid arthritis (2014), Arthritis Rheumatol., 66, 1723-1733.
    View publication on PubMed
Search for more literature for 2.3.1.57

Protein Variants

Protein Variants Comment Organism
additional information small interfering RNAs (siRNAs) against SSAT-1 are transfected weekly in rheumatoid arthritis synovial fibroblasts Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
diminazene aceturate inhibitor of SSAT-1, does not induce apoptosis Homo sapiens
Pentamidine induces apoptosis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme transforms polyamines into putrescine ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P21673
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast synovial fibroblasts from patients with rheumatoid arthritis or osteoarthritis Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme transforms polyamines into putrescine Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
spermidine/spermine N1-acetyltransferase
-
 Homo sapiens
spermidine/spermine N1-acetyltransferase 1
-
 Homo sapiens
SSAT-1
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme inhibition also inhibits ongoing joint destruction. Enzyme inhibition or gene silencing by transfection of siRNA targeting SSAT-1 increases 5-methylcytosine levels/PMF-1 promoter methylation within 21 days Homo sapiens