Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.57 extracted from

  • Klempan, T.; Rujescu, D.; Mérette, C.; Himmelman, C.; Sequeira, A.; Canetti, L.; Fiori, L.; Schneider, B.; Bureau, A.; Turecki, G.
    Profiling brain expression of the spermidine/spermine N1-acetyltransferase 1 (SAT1) gene in suicide (2009), Am. J. Med. Genet. B Neuropsychiatr. Genet., 150, 934-943.
    View publication on PubMed
Search for more literature for 2.3.1.57

Cloned(Commentary)

Cloned (Comment) Organism
SAT1, microarray expression analysis in brains of control individuals and depressed individuals who have died by suicide, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + spermidine Homo sapiens
-
 CoA + N1-acetylspermidine
-
 ?
acetyl-CoA + spermine Homo sapiens
-
 CoA + N1-acetylspermine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 French-Canadian population
-

Source Tissue

Source Tissue Comment Organism Textmining
brain cortex
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + spermidine
-
 Homo sapiens CoA + N1-acetylspermidine
-
 ?
acetyl-CoA + spermine
-
 Homo sapiens CoA + N1-acetylspermine
-
 ?

Synonyms

Synonyms Comment Organism
SAT1
-
 Homo sapiens
spermidine/spermine N1-acetyltransferase 1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction altered expression of SAT1 in the polyamine stress response, across multiple brain regions between control individuals and depressed individuals who have died by suicide, overview Homo sapiens
physiological function SAT1 is the rate-limiting enzyme involved in catabolism of the polyamines spermidine and spermine Homo sapiens