Application | Comment | Organism |
---|---|---|
medicine | in kidneys subjected to ischemia-reperfusion injury, one mechanism through which increased expression of SSAT may cause cellular injury and organ damage is through induction of DNA damage and the disruption of cell cycle | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | activity of SSAT is increased 28fold in tetracycline-induced cells. Increase in SSAT levels in HEK-293 cells leads to depletion of polyamines and elevation in the enzymatic activities of ornithine decarboxylase and S-adenosylmethionine decarboxylase, suggestive of a compensatory reaction to increased polyamine catabolism. Increased expression of SSAT also leads to DNA damage and G2 arrest | Homo sapiens | - |
kidney | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
spermidine/spermine N1-acetyltransferase | - |
Homo sapiens |
SSAT | - |
Homo sapiens |