Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | N1,N11-diethylnorspermine induces SSAT activity by post-mRNA regulation | Mus musculus |
Cloned (Comment) | Organism |
---|---|
full-length cDNA is cloned and expressed in Escherichia coli M15, generation of a transgenic mouse line systemically overexpressing SSAT, overexpression alters polyamine pools and sensitize cells to the antiproliferative activity of N1,N11-diethylnorspermine | Mus musculus |
General Stability | Organism |
---|---|
N1,N11-diethylnorspermine stabilizes | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | SSAT catalyzes together with polyamine oxidase the back-conversion of spermine to spermidine and the latter to putrescine, a function lowering polyamine pools by facilitating their catabolism and excretion | ? | - |
? | |
additional information | Mus musculus | polyamine catabolic enzyme | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
transgenic mouse line overexpressing SSAT | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fetus | primary fetal fibroblasts | Mus musculus | - |
fibroblast | primary fetal fibroblasts | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + spermidine | - |
Mus musculus | CoA + N1-acetylspermidine | - |
? | |
acetyl-CoA + spermine | - |
Mus musculus | CoA + N1-acetylspermine | - |
? | |
additional information | SSAT catalyzes together with polyamine oxidase the back-conversion of spermine to spermidine and the latter to putrescine, a function lowering polyamine pools by facilitating their catabolism and excretion | Mus musculus | ? | - |
? | |
additional information | polyamine catabolic enzyme | Mus musculus | ? | - |
? |