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Literature summary for 2.3.1.57 extracted from

  • Vujcic, S.; Halmekyto, M.; Diegelman, P.; Gan, G.; Kramer, D.L.; Janne, J.; Porter, C.W.
    Effects of conditional overexpression of spermidine/spermine N1-acetyltransferase on polyamine pool dynamics, cell growth, and sensitivity to polyamine analogs (2000), J. Biol. Chem., 275, 38319-38328.
    View publication on PubMed
Search for more literature for 2.3.1.57

Activating Compound

Activating Compound Comment Organism Structure
additional information N1,N11-diethylnorspermine induces SSAT mRNA and activity Mus musculus
additional information N1,N11-diethylnorspermine induces SSAT mRNA and activity Homo sapiens

Application

Application Comment Organism
medicine development of SSAT induction strategies to circumvent the ability of tumor cells to escape the antitumor activity of polyamine inhibitors such as alpha-difluoromethylornithine by salvaging exogenous polyamines Homo sapiens
pharmacology compounds capable of potently inducing SSAT and having favorable pharmacological properties in animals are potential anticancer agents Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
complete SSAT cDNA is cloned, tetracyclin-regulated cDNA is expressed in MCF-7 human breast carcinoma cells, conditional overexpression lowers polyamine pools, inhibits cell growth and enhances growth sensitivity to certain analogs Homo sapiens
SSAT gene is cloned, tetracyclin-regulated gene lacking the 5’-flanking region is expressed in MCF-7 human breast carcinoma cells, conditional overexpression lowers polyamine pools, inhibits cell growth and enhances growth sensitivity to certain analogs Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information doxycycline suppresses SSAT gene expression Homo sapiens
additional information doxycycline suppresses SSAT gene expression Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus polyamine catabolic enzyme ?
-
 ?
additional information Homo sapiens polyamine catabolic enzyme ?
-
 ?
additional information Mus musculus enzyme plays an efficient role in maintaining polyamine pool homeostasis during challenges with exogenous polyamines ?
-
 ?
additional information Homo sapiens enzyme plays an efficient role in maintaining polyamine pool homeostasis during challenges with exogenous polyamines ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human cDNA expressed in MCF-7 human breast carcinoma cells
-
Mus musculus
-
 recombinant enzyme, expressed in MCF-7 human breast carcinoma cells
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Mus musculus
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + N1-acetylspermine
-
 Mus musculus CoA + N1,N12-diacetylspermine
-
 ?
acetyl-CoA + N1-acetylspermine
-
 Homo sapiens CoA + N1,N12-diacetylspermine
-
 ?
acetyl-CoA + spermidine
-
 Mus musculus CoA + N1-acetylspermidine product is exclusively N1-acetylspermidine ?
acetyl-CoA + spermidine
-
 Homo sapiens CoA + N1-acetylspermidine product is exclusively N1-acetylspermidine ?
acetyl-CoA + spermine
-
 Mus musculus CoA + N1-acetylspermine
-
 ?
acetyl-CoA + spermine
-
 Homo sapiens CoA + N1-acetylspermine
-
 ?
additional information not: putrescine Mus musculus ?
-
 ?
additional information not: putrescine Homo sapiens ?
-
 ?
additional information polyamine catabolic enzyme Mus musculus ?
-
 ?
additional information polyamine catabolic enzyme Homo sapiens ?
-
 ?
additional information enzyme plays an efficient role in maintaining polyamine pool homeostasis during challenges with exogenous polyamines Mus musculus ?
-
 ?
additional information enzyme plays an efficient role in maintaining polyamine pool homeostasis during challenges with exogenous polyamines Homo sapiens ?
-
 ?