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Literature summary for 2.3.1.51 extracted from

  • Faris, R.; Fan, Y.; De Angulo, A.; Chapkin, R.; Degraffenried, L.; Jolly, C.
    Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential for murine CD4+ T cell metabolic activation (2014), Biochim. Biophys. Acta, 1841, 1475-1482.
No PubMed abstract available
Search for more literature for 2.3.1.51

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate Mus musculus
-
 CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
helper T-lymphocyte CD4+ Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
 Mus musculus CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
glycerol-3-phosphate acyltransferase-1
-
 Mus musculus
GPAT-1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction striking decreases in both the oxygen consumption rate and the extracellular acidification rate are observed in enzyme-deficient CD4+ T cells following CD3/CD28 stimulation indicating an inherent cellular defect in energy production. In addition, the spare respiratory capacity and the mitochondrial membrane potential of these CD4+T cells is significantly decreased Mus musculus
physiological function the enzyme is essential for the response to the increased metabolic demands associated with T cell activation Mus musculus