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Literature summary for 2.3.1.51 extracted from
- Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria (2011), J. Lipid Res., 52, 451-462.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in HEK-293 cell | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0048 | - |
1-oleoyl-sn-glycerol 3-phosphate | pH 7.4, 30°C | Homo sapiens |  |
| 0.0055 | - |
1-oleoyl-sn-glycerol 3-phosphate | pH 7.4, 37°C | Homo sapiens | |
| 0.0163 | - |
oleoyl-CoA | pH 7.4, 37°C | Homo sapiens | |
| 0.0215 | - |
oleoyl-CoA | pH 7.4, 30°C | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| mitochondrion | - |
Homo sapiens | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 43380 | - |
x * 43380, claculated | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9NRZ7 | - |
- |
| Homo sapiens | Q9NUQ2 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | - |
Homo sapiens | - |
| kidney | high expression | Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| lung | - |
Homo sapiens | - |
| additional information | isoform AGPAT3 appears to be ubiquitously expressed across the tissues examined. Comparison of isoforms AGPAT3, AGPAT4, AGPAT5 expression in different tissues | Homo sapiens | - |
| pancreas | high expression | Homo sapiens | - |
| spleen | - |
Homo sapiens | - |
| testis | high expression | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate | about half of the rate with oleoyl-CoA | Homo sapiens | CoA + 1-oleoyl-2-arachidonoyl-sn-glycerol 3-phosphate | - |
? | |
| heptadecanoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate | about half of the rate with oleoyl-CoA | Homo sapiens | CoA + 1-oleoyl-2-heptadecanoyl-sn-glycerol 3-phosphate | - |
? | |
| linoleoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate | about half of the rate with oleoyl-CoA | Homo sapiens | CoA + 1-oleoyl-2-linoleoyl-sn-glycerol 3-phosphate | - |
? | |
| additional information | isoform AGPAT3 shows broad preference for lysophosphatidic acids containing saturated or unsaturated fatty acids C16:0-C20:4 and significant esterification of lysophosphatidylinositol in the presence of oleoyl-CoA | Homo sapiens | ? | - |
? | |
| additional information | isoform AGPAT5 demonstrates significant acyltransferase activity toward lysophosphatidylethanolamine in the presence of oleoyl-CoA | Homo sapiens | ? | - |
? | |
| oleoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate | both substrates are preferred | Homo sapiens | CoA + 1,2-dioleoyl-sn-glycerol 3-phosphate | - |
? | |
| palmitoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate | about 40% of the rate with oleoyl-CoA | Homo sapiens | CoA + 1-oleoyl-2-palmitoyl-sn-glycerol 3-phosphate | - |
? | |
| stearoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate | about 40% of the rate with oleoyl-CoA | Homo sapiens | CoA + 1-oleoyl-2-stearoyl-sn-glycerol 3-phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 43380, claculated | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AGPAT3 | - |
Homo sapiens |
| AGPAT5 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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