Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.51 extracted from

  • Agarwal, A.K.; Garg, A.
    Enzymatic activity of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 11: upregulated in breast and cervical cancers (2010), J. Lipid Res., 51, 2143-2152.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.51

Application

Application Comment Organism
medicine expression of isoform AGPAT11 mRNA is signifi cantly upregulated in human breast, cervical, and colorectal cancer tissues Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in CHO cell, HeLa cell and HEK-293 cell Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q7L5N7
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heptadecanoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
 Homo sapiens CoA + 1-oleoyl-2-heptadecanoyl-sn-glycerol 3-phosphate
-
 ?
linoleoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
 Homo sapiens CoA + 1-oleoyl-2-linoleoyl-sn-glycerol 3-phosphate
-
 ?
additional information isoform AGPAT11 shows broad preferences for the lysophosphatidic acid containing saturated fatty acids C16:0-C18:0, including lysophosphatidic acid containing oleic acid. Lysophosphatidic acid with fatty acid C20:4 is acylated at only about one-half maximal rate compared with others. The preferred acyl donor follows the decreasing order of C18:1,C16:0, C18:2, C17:0. Fatty acyl-CoA consisting of short-chain fatty acids C8:0 to C13:0 and very long-chain from C20:0 to C26:0 are not substrates. Enzyme does not display glycerol-3-phosphate acyltransferase activity Homo sapiens ?
-
 ?
oleoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate both substrates are preferred Homo sapiens CoA + 1,2-dioleoyl-sn-glycerol 3-phosphate
-
 ?
palmitoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
 Homo sapiens CoA + 1-oleoyl-2-palmitoyl-sn-glycerol 3-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
AGPAT11
-
 Homo sapiens
LPCAT2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens expression of isoform AGPAT11 mRNA is significantly upregulated in human breast, cervical, and colorectal cancer tissues up